A fragile site in the human U2 small nuclear RNA gene cluster is revealed by adenovirus type 12 infection.

D M Durnam; J C Menninger; S H Chandler; P P Smith; J K McDougall

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A fragile site in the human U2 small nuclear RNA gene cluster is revealed by adenovirus type 12 infection.

机译：人类U2小核RNA基因簇中的一个脆弱位点由12型腺病毒感染揭示。

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Using in situ hybridization, we found that the U2 small nuclear RNA gene cluster mapped very close to and was frequently disrupted by the gaps and breaks induced specifically in the human 17q21-q22 region by highly oncogenic adenovirus type 12 (Ad12). Restriction mapping revealed no structural alterations in the U2 gene locus as a result of Ad12 infection. Likewise, no Ad12-induced alterations in U2 RNA levels were detected. We estimate that the maximum size of the region specifically disrupted by this virus was less than 350 to 700 kilobases. A comparison of these data with similar data regarding biochemically induced fragile sites was made.

机译：使用原位杂交，我们发现U2小核RNA基因簇的位置非常接近，并且经常被高致癌性12型腺病毒（Ad12）在人17q21-q22区中特异性诱导的缺口和断裂所破坏。限制性作图表明，Ad12感染未导致U2基因位点的结构改变。同样，未检测到Ad12诱导的U2 RNA水平改变。我们估计，被该病毒特别破坏的区域的最大大小小于350至700千碱基。将这些数据与关于生化诱导的脆弱位点的类似数据进行比较。

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《Molecular and Cellular Biology》 |1988年第5期|共5页
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D M Durnam; J C Menninger; S H Chandler; P P Smith; J K McDougall;
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1. Adenovirus type 12-induced fragility of the human RNU2 locus requires U2 small nuclear RNA transcriptional regulatory elements. [J] . A D Bailey, Z Li, T Pavelitz, Molecular and Cellular Biology . 1995,第11期

机译：人类RNU2基因座的12型腺病毒诱导的脆性需要U2小核RNA转录调控元件。
2. Generation of a new adenovirus type 12-inducible fragile site by insertion of an artificial U2 locus in the human genome. [J] . Y P Li, R Tomanin, J R Smiley, Molecular and Cellular Biology . 1993,第10期

机译：通过在人基因组中插入人工U2基因座，可产生新的12型腺病毒诱导型脆弱位点。
3. The transcriptionally competent U2 gene is necessary and sufficient for adenovirus type 12 induction of the fragile site at 17q21-22. [J] . S Gargano, P Wang, E Rusanganwa, Molecular and Cellular Biology . 1995,第11期

机译：具有转录能力的U2基因对于诱导17q21-22处的易碎位点的腺病毒12型是必要和充分的。
4. Prediction of back-splicing sites reveals sequence compositional features of human circular RNAs [C] . Jun Wang, Liangjiang Wang IEEE International Conference on Computational Advances in Bio and Medical Sciences . 2017

机译：反向剪接位点的预测揭示了人类环状RNA的序列组成特征
5. PHYSICAL STUDIES OF THE ORGANIZATION AND TRANSCRIPTION OF THE GENOME OF HUMAN ADENOVIRUS TYPE 12. [D] . SMILEY, JAMES RICHARD. 1977

机译：12型人类腺病毒基因组的组织和转录的物理研究。
6. A fragile site in the human U2 small nuclear RNA gene cluster is revealed by adenovirus type 12 infection. [O] . D M Durnam, J C Menninger, S H Chandler, 1988

机译：人类U2小核RNA基因簇中的一个脆弱位点由12型腺病毒感染揭示。
7. A fragile site in the human U2 small nuclear RNA gene cluster is revealed by adenovirus type 12 infection. [O] . Durnam, D M, Menninger, J C, Chandler, S H, 1988

机译：人类U2小核RNA基因簇中的一个脆弱位点由12型腺病毒感染揭示。
8. Adenovirus Microsatellite Reveals Dynamics of Transmission during a Recent Epidemic of Human Adenovirus Serotype 14 Infection. [R] . Houng, H. H., Lott, L., Gong, H., 2009

机译：腺病毒微卫星揭示了近期人类腺病毒血清型14感染流行病的传播动态。

A fragile site in the human U2 small nuclear RNA gene cluster is revealed by adenovirus type 12 infection.

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