首页> 外文期刊>Molecular and Cellular Biology >An RNA Binding Protein Negatively Controlling Differentiation in Fission Yeast
【24h】

An RNA Binding Protein Negatively Controlling Differentiation in Fission Yeast

机译:负控制裂变酵母中的分化的RNA结合蛋白。

获取原文
           

摘要

The fission yeast Schizosaccharomyces pombe starts sexual development when starved for nutrients and simultaneously activated by mating pheromones. We have identified a new gene regulating the onset of this process. This gene, callednrd1 +, encodes a typical RNA binding protein that preferentially binds poly(U). Deletion ofnrd1 + causes cells to initiate sexual development without nutrient starvation. We have found that the biological role of nrd1 + is to block the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation.
机译:裂殖酵母 Schizosaccharomyces pombe 在缺乏营养时会开始有性发育,并同时被信息素交配激活。我们已经确定了调节该过程开始的新基因。这个名为 nrd1 + 的基因编码一个典型的RNA结合蛋白,该蛋白优先结合poly(U)。删除 nrd1 + 会导致细胞在没有营养饥饿的情况下启动性发育。我们发现 nrd1 + 的生物学作用是通过抑制共轭和减数分裂所必需的Ste11调控基因来阻止性发育,直到细胞达到临界水平饥饿

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号