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首页> 外文期刊>Molecular and Cellular Biology >CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes
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CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes

机译：CHD8是一种ATP依赖的染色质重塑因子，可调节β-连环蛋白靶基因。

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ATP-dependent chromatin remodeling by the CHD family of proteins plays an important role in the regulation of gene transcription. Here we report that full-length CHD8 interacts directly with β-catenin and that CHD8 is also recruited specifically to the promoter regions of several β-catenin-responsive genes. Our results indicate that CHD8 negatively regulates β-catenin-targeted gene expression, since short hairpin RNA against CHD8 results in the activation of several β-catenin target genes. This regulation is also conserved through evolution; RNA interference against kismet, the apparent Drosophila ortholog of CHD8, results in a similar activation of β-catenin target genes. We also report the first demonstration of chromatin remodeling activity for a member of the CHD6-9 family of proteins, suggesting that CHD8 functions in transcription through the ATP-dependent modulation of chromatin structure.
机译：CHD家族的蛋白质对ATP的染色质重塑在基因转录的调控中起着重要的作用。在这里，我们报道全长CHD8与β-catenin直接相互作用，并且CHD8也被专门募集到一些β-catenin反应基因的启动子区域。我们的结果表明，CHD8负调节β-catenin靶向基因的表达，因为针对CHD8的短发夹RNA导致多个β-catenin靶向基因的激活。这种调节也通过进化得到保留。 RNA对 kismet （CHD8的明显<果>果蝇直系同源物）的干扰导致β-catenin靶基因的类似激活。我们还报告了CHD6-9家族蛋白成员的染色质重塑活性的首次证明，这表明CHD8在转录中通过染色质结构的ATP依赖性调节而起作用。

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