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Recent advances in synthetic facets of immensely reactive azetidines

机译：巨大反应性氮杂环丁烷的合成方面的最新进展

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The synthetic chemistry of azetidine constitutes an important yet undeveloped research area, in spite of their ubiquity in natural products and importance in medicinal chemistry. Their aptness as amino acid surrogates along with their potential in peptidomimetic and nucleic acid chemistry is considered remarkable. Azetidines also possess important prospects in other settings such as catalytic processes including Henry, Suzuki, Sonogashira and Michael additions. They also represent an important class of strained compounds making them excellent candidates for ring-opening and expansion reactions. With this in mind, the present review article addresses the recent developments in synthetic strategies towards functionalized azetidines along with their versatility as heterocyclic synthons.
机译：尽管氮杂环丁烷的合成化学在天然产物中无处不在并且在药物化学中很重要，但其构成了一个重要但尚未开发的研究领域。它们作为氨基酸替代物的适应性以及它们在拟肽和核酸化学中的潜力被认为是显着的。氮杂环丁烷在其他场合也具有重要的前景，例如催化过程，包括亨利，铃木，索诺加希拉和迈克尔的加成。它们也代表了重要的一类应变化合物，使其成为开环和扩环反应的极佳候选者。考虑到这一点，本文综述了功能化氮杂环丁烷合成策略的最新进展，以及它们作为杂环合成子的多功能性。

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