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Dietary intake of magnesium-L-threonate alleviates memory deficits induced by developmental lead exposure in rats

机译:膳食摄入L-苏糖酸镁可减轻大鼠发育性铅暴露引起的记忆力减退

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Elevation of brain magnesium enhances cognitive capacity. Chronic lead (Pb) exposure has been implicated in the impairment of cognition. Whether elevation of brain magnesium rescues the impairment of memory by chronic Pb exposure is still unclear. Here we investigated the effect and possible mechanisms of chronic dietary intake of magnesium-L-threonate (MgT) on impaired spatial memory by chronic developmental Pb exposure in rats. We found that MgT rescued impaired spatial memory ability in Pb-exposed rats. This positive effect is relative to increasing dendritic spine density and the expression of NR2A and GluR1.
机译:脑镁的升高可增强认知能力。慢性铅(Pb)暴露与认知功能受损有关。尚不清楚大脑镁的升高是否能通过长期的铅暴露来挽救记忆障碍。在这里,我们研究了慢性饮食中长期摄取铅对大鼠饮食的影响,并探讨了长期饮食摄入镁- L -苏氨酸镁(MgT)的可能。我们发现MgT挽救了铅暴露大鼠中受损的空间记忆能力。这种积极作用与增加树突棘密度以及NR2A和GluR1的表达有关。

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