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首页> 外文期刊>RSC Advances >Poly(anhydride) nanoparticles act as effective adjuvants to elicit a persistent immune response
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Poly(anhydride) nanoparticles act as effective adjuvants to elicit a persistent immune response

机译：聚（酸酐）纳米颗粒可作为有效佐剂引发持久性免疫反应

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In order to evoke an efficient immune response to prevent and eliminate infectious and malignant diseases, it is critical to develop more effective and safer vaccines or adjuvants to enhance the antigenicity of natural antigens. The objective of this study is to produce nanoparticles composed of poly(methyl vinyl ether-co-maleic anhydride) (PVM/MA) and the model antigen ovalbumin (OVA), termed as p-OVAs, to assess the antigen sustained release property and the effectiveness in the immune responses in BALB/c mice. The results showed that the p-OVAs were spherical, evenly distributed with an average diameter of ～290 nm, and had a sustained release property in vitro. After immunization of BALB/C mice with p-OVA, strong OVA-specific cellular and humoral immune responses were observed in vivo. The whole blood cell tests and histological results also suggested that immunization with p-OVA is both effective and relatively safe. Overall, here we provide new insight into future vaccine and/or adjuvant design with PVM/MA, which is promising for the immunotherapy of cancer and autoimmune diseases.
机译：为了引起有效的免疫反应以预防和消除传染性和恶性疾病，开发更有效和更安全的疫苗或佐剂以增强天然抗原的抗原性至关重要。这项研究的目的是生产由聚（甲基乙烯基醚- co <​​/ em>-马来酸酐）（PVM / MA）和模型抗原卵清蛋白（OVA）（称为p-OVA）组成的纳米颗粒，评估BALB / c小鼠的抗原持续释放特性和免疫应答的有效性。结果表明，p-OVA为球形，平均粒径约290 nm，具有体外持续释放特性。用p-OVA免疫BALB / C小鼠后，在体内 观察到了强烈的OVA特异性细胞和体液免疫反应。全血细胞测试和组织学结果也表明，p-OVA免疫既有效又相对安全。总体而言，在这里，我们提供了有关使用PVM / MA的未来疫苗和/或佐剂设计的新见解，这对于癌症和自身免疫性疾病的免疫疗法很有希望。

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