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首页> 外文期刊>RSC Advances >Growth of epithelial cells on films of enzymatically synthesized poly(gallic acid) crosslinked to carboxymethylcellulose
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Growth of epithelial cells on films of enzymatically synthesized poly(gallic acid) crosslinked to carboxymethylcellulose

机译：酶法合成聚没食子酸与羧甲基纤维素交联的膜上皮细胞的生长

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摘要

Poly(gallic acid), a novel polymer obtained by enzymatic polymerization of gallic acid, was successfully cross-linked to carboxymethylcellulose using citric acid as a cross-linker. Non-woven sheets were prepared with the resulting copolymer and their in vitro biocompatibility was assessed. The results on the characterizations of the produced films by mechanical tests, water vapour permeability, contact angle, and antioxidant activity by electronic paramagnetic resonance were adequate for skin tissue regeneration. Films were also decomposed under physiological conditions using universal buffers at pH 3, 7 and 10. In vitro experiments with fibroblast-like and epithelial-like cells showed good adhesion and proliferation onto the PGAL-co-CMC sheets. These non-woven sheets can consequently be considered as novel biocompatible and biodegradable films with high-responsiveness for biomedical or tissue engineering applications.
机译：聚没食子酸是一种通过没食子酸的酶促聚合反应获得的新型聚合物，它利用柠檬酸作为交联剂成功地交联到了羧甲基纤维素上。用所得共聚物制备非织造片材，并评估它们的体外生物相容性。通过机械测试，水蒸气渗透性，接触角和通过电子顺磁共振进行的抗氧化活性表征所制备的膜的结果足以用于皮肤组织再生。在生理条件下，使用通用缓冲液在pH 3、7和10下也能分解膜。体外实验中，成纤维细胞样和上皮样细胞在PGAL- co上具有良好的粘附和增殖 -CMC工作表。这些非织造片材因此可以被认为是具有高响应性的新颖的生物相容性和可生物降解的膜，用于生物医学或组织工程应用。

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