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首页> 外文期刊>RSC Advances >Chinese liquor extract enhances inflammation resistance in RAW 264.7 and reduces aging in Caenorhabditis elegans
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Chinese liquor extract enhances inflammation resistance in RAW 264.7 and reduces aging in Caenorhabditis elegans

机译：中国白酒提取物增强RAW 264.7中的抗炎性并减少秀丽隐杆线虫的衰老

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摘要

Recent reports have indicated that the ingredients in Chinese liquor possess multiple bioactivities. The objective of this study was to evaluate the potential effects of Chinese liquor extract (CME) on the resistance to inflammation in mononuclear macrophages (RAW 264.7 cell line) and aging in Caenorhabditis elegans ( C. elegans ). The results showed that CME suppressed key lipopolysaccharide (LPS)-induced pro-inflammatory mediators, tumor necrosis factor-α, and nitric oxide in vitro . Furthermore, CME inhibited activation of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/AKT pathways in LPS-stimulated cells. Further studies also showed that CME improved stress resistance of nematodes under infection conditions. Moreover, CME increased the expression of immune-related genes, such as lys-7 . Based on these results, our findings provide mechanistic insights about the protection provided by CME against LPS-induced inflammation in RAW 264.7 cells, namely, inhibition of MAPK and PI3K/AKT pathways, as well as its capability against Pseudomonas aeruginosa - and Staphylococcus aureus -induced aging in C. elegans .
机译：最近的报道表明，白酒中的成分具有多种生物活性。这项研究的目的是评估中国白酒提取物（CME）对单核巨噬细胞（RAW 264.7细胞系）的炎症抵抗和秀丽隐杆线虫（C. elegans）老化的潜在影响。结果表明，CME在体外抑制了关键脂多糖（LPS）诱导的促炎性介质，肿瘤坏死因子-α和一氧化氮。此外，CME抑制LPS刺激的细胞中促分裂原活化的蛋白激酶（MAPK）和磷脂酰肌醇3激酶（PI3K）/ AKT途径的激活。进一步的研究还表明，CME可改善感染条件下线虫的抗逆性。此外，CME增加了免疫相关基因如lys-7的表达。基于这些结果，我们的发现提供了有关CME对LP 26诱导的RAW 264.7细胞中LPS诱导的炎症的保护的机械性见解，即对MAPK和PI3K / AKT通路的抑制及其对铜绿假单胞菌和金黄色葡萄球菌的抑制能力。诱导线虫衰老。

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