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首页> 外文期刊>RSC Advances >Chinese liquor extract enhances inflammation resistance in RAW 264.7 and reduces aging in Caenorhabditis elegans
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Chinese liquor extract enhances inflammation resistance in RAW 264.7 and reduces aging in Caenorhabditis elegans

机译：中国液体提取物增强了原料264.7中的炎症抗性，减少了秀丽隐杆线虫

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摘要

Recent reports have indicated that the ingredients in Chinese liquor possess multiple bioactivities. The objective of this study was to evaluate the potential effects of Chinese liquor extract (CME) on the resistance to inflammation in mononuclear macrophages (RAW 264.7 cell line) and aging in Caenorhabditis elegans (C. elegans). The results showed that CME suppressed key lipopolysaccharide (LPS)-induced pro-inflammatory mediators, tumor necrosis factor-, and nitric oxide in vitro. Furthermore, CME inhibited activation of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/AKT pathways in LPS-stimulated cells. Further studies also showed that CME improved stress resistance of nematodes under infection conditions. Moreover, CME increased the expression of immune-related genes, such as lys-7. Based on these results, our findings provide mechanistic insights about the protection provided by CME against LPS-induced inflammation in RAW 264.7 cells, namely, inhibition of MAPK and PI3K/AKT pathways, as well as its capability against Pseudomonas aeruginosa- and Staphylococcus aureus-induced aging in C. elegans.
机译：最近的报道表明，中国酒的成分具有多种生物活跃。本研究的目的是评估中国液体提取物（CME）对单核巨噬细胞（RAW 264.7细胞系）抗炎症的潜在效果和在Caenorhabdiseldise中的老化（C.秀丽隐杆线）。结果表明，CME抑制了关键的脂多糖（LPS）诱导的促炎介质，肿瘤坏死因子和体外一氧化氮。此外，CME在LPS刺激的细胞中抑制丝裂剂活化蛋白激酶（MAPK）和磷脂酰肌醇-3激酶（PI3K）/ AKT途径的活化。进一步的研究还表明，CME在感染条件下改善了线虫的应力性。此外，CME增加了免疫相关基因的表达，例如Lys-7。基于这些结果，我们的研究结果提供了关于CME对原始264.7细胞中的LPS诱导的炎症提供的保护的机械洞察，即MAPK和PI3K / AKT途径，以及其对假单胞菌铜绿假单胞菌和金黄色葡萄球菌的能力 - 在秀丽隐杆线上诱导老化。

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  • 来源
    《RSC Advances》 |2018年第67期|共9页
  • 作者

    Liu Jie; Wang Huailing; Liu Xiaoyu; Zhang Guohao; Yang Pingchang; Liu Zhigang;

  • 作者单位

    Shenzhen Univ Dept Allergy Affiliated Hosp 3 Shenzhen 518020 Peoples R China;

    Shenzhen Univ Dept Allergy Affiliated Hosp 3 Shenzhen 518020 Peoples R China;

    Shenzhen Univ Dept Allergy Affiliated Hosp 3 Shenzhen 518020 Peoples R China;

    Shenzhen Univ Res Ctr Allergy &

    Immunol Sch Med Shenzhen 518060 Peoples R China;

    Shenzhen Univ Dept Allergy Affiliated Hosp 3 Shenzhen 518020 Peoples R China;

    Shenzhen Univ Dept Allergy Affiliated Hosp 3 Shenzhen 518020 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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