• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >High-throughput lipidomics reveal mirabilite regulating lipid metabolism as anticancer therapeutics
【24h】

High-throughput lipidomics reveal mirabilite regulating lipid metabolism as anticancer therapeutics

机译：高通量脂质组学揭示了芒硝调节脂质代谢作为抗癌疗法

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Altered lipid metabolism is an emerging hallmark of cancers. Mirabilite has a therapeutic effect on colorectal cancer (CRC); however, its metabolic mechanism remains unclear. This study aims to explore the potential therapeutic targets of mirabilite protection against colorectal cancer in APC ~(min/+) mice model. Oral administration of mirabilite was started from the ninth month, while the same dosage of distilled water was given to both the control group and the model group. Based on lipidomics, we collected serum samples of all mice at the 20 ~(th) week and used a non-targeted method to identify the lipid biomarkers of CRC. Compared with C57BL/6J mice, the metabolic profile of CRC model mice was significantly disturbed, and we identified that 25 lipid-related biomarkers, including linoleic acid, 2-hydroxybutyric acid, 6-deoxocastasterone, hypoxanthine, PC(16:1), PC(18:4), and retinyl acetate, were associated with CRC. According to the abovementioned results, there were six lipid molecules with significant differences that can be used as new targets for handling of CRC through six metabolic pathways, namely, linoleic acid metabolism, retinol metabolism, propanoate metabolism, arachidonic acid metabolism, biosynthesis of unsaturated fatty acids and purine metabolism. Compared with the model group, the metabolic profiles of these disorders tend to recover after treatment. These results indicated that the lipid molecules associated with CRC were regulated by mirabilite. In addition, we identified seven key lipid molecules, of which four had statistical significance. After administration of mirabilite, all disordered metabolic pathways showed different degrees of regulation. In conclusion, high-throughput lipidomics approach revealed mirabilite regulating the altered lipid metabolism as anticancer therapeutics.
机译：脂质代谢改变是癌症的新兴标志。芒硝对结直肠癌（CRC）有治疗作用;然而，其代谢机制仍不清楚。这项研究旨在探讨在APC〜（min / +）小鼠模型中，芒硝保护结肠直肠癌的潜在治疗靶点。从第九个月开始口服芒硝，同时给予对照组和模型组相同剂量的蒸馏水。基于脂质组学，我们在第20周时收集了所有小鼠的血清样本，并使用非靶向方法来鉴定CRC的脂质生物标志物。与C57BL / 6J小鼠相比，CRC模型小鼠的代谢谱受到显着干扰，我们鉴定出25种与脂质相关的生物标记物，包括亚油酸，2-羟基丁酸，6-脱氧castasterasterone，次黄嘌呤，PC（16：1）， PC（18：4）和乙酸视黄酯与CRC相关。根据上述结果，存在六个具有显着差异的脂质分子，它们可以作为通过六种代谢途径处理CRC的新靶标，即亚油酸代谢，视黄醇代谢，丙酸酯代谢，花生四烯酸代谢，不饱和脂肪的生物合成。酸和嘌呤代谢。与模型组相比，这些疾病的代谢特征在治疗后趋于恢复。这些结果表明，与CRC相关的脂质分子受芒硝调节。此外，我们鉴定了七个关键脂质分子，其中四个具有统计学意义。施用芒硝后，所有紊乱的代谢途径均表现出不同程度的调节。总之，高通量脂质组学方法揭示了芒硝调节抗脂质代谢的改变作为抗癌药物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号