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High-throughput lipidomics reveal mirabilite regulating lipid metabolism as anticancer therapeutics

机译：高通量脂多元族菌揭示了Mirabilite调节脂质代谢作为抗癌治疗方法

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Altered lipid metabolism is an emerging hallmark of cancers. Mirabilite has a therapeutic effect on colorectal cancer (CRC); however, its metabolic mechanism remains unclear. This study aims to explore the potential therapeutic targets of mirabilite protection against colorectal cancer in APC(min/+) mice model. Oral administration of mirabilite was started from the ninth month, while the same dosage of distilled water was given to both the control group and the model group. Based on lipidomics, we collected serum samples of all mice at the 20th week and used a non-targeted method to identify the lipid biomarkers of CRC. Compared with C57BL/6J mice, the metabolic profile of CRC model mice was significantly disturbed, and we identified that 25 lipid-related biomarkers, including linoleic acid, 2-hydroxybutyric acid, 6-deoxocastasterone, hypoxanthine, PC(16:1), PC(18:4), and retinyl acetate, were associated with CRC. According to the abovementioned results, there were six lipid molecules with significant differences that can be used as new targets for handling of CRC through six metabolic pathways, namely, linoleic acid metabolism, retinol metabolism, propanoate metabolism, arachidonic acid metabolism, biosynthesis of unsaturated fatty acids and purine metabolism. Compared with the model group, the metabolic profiles of these disorders tend to recover after treatment. These results indicated that the lipid molecules associated with CRC were regulated by mirabilite. In addition, we identified seven key lipid molecules, of which four had statistical significance. After administration of mirabilite, all disordered metabolic pathways showed different degrees of regulation. In conclusion, high-throughput lipidomics approach revealed mirabilite regulating the altered lipid metabolism as anticancer therapeutics.
机译：改变的脂质代谢是癌症的新兴标志。 Mirabilite对结直肠癌（CRC）具有治疗效果;然而，其代谢机制仍不清楚。本研究旨在探讨APC（MIN / +）小鼠模型中含有霉菌癌的潜在治疗靶标。从第九个月开始口服mirabilite，而对照组和模型组给予相同的蒸馏水剂量。基于脂类族学，我们在第20周收集了所有小鼠的血清样品，并使用了非靶向方法来鉴定CRC的脂质生物标志物。与C57BL / 6J小鼠相比，CRC模型小鼠的代谢分布显着受到干扰，我们确定了25个脂质相关的生物标志物，包括亚油酸，2-羟基丁酸，6-脱氧糖，缺氧，PC（16：1）， PC（18：4）和乙酸乙烯酯与CRC相关。根据上述结果，六种脂质分子具有显着差异，可用作通过六种代谢途径处理CRC的新靶标，即亚油酸代谢，视黄醇代谢，丙种代谢，花生素代谢，不饱和脂肪的生物合成酸和嘌呤代谢。与模型组相比，这些障碍的代谢谱趋于在治疗后恢复。这些结果表明，与CRC相关的脂质分子由Mirabilite调节。此外，我们确定了七种关键的脂质分子，其中四个具有统计学意义。在施用Mirabilite后，所有无序的代谢途径显示出不同程度的调节。总之，高通量脂质族方法揭示了Mirabilite调节改变的脂质代谢作为抗癌治疗方法。

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  • 来源
    《RSC Advances》 |2018年第62期|共11页
  • 作者

    Zhang Hong-lian; Zhang Ai-hua; Zhou Xiao-hang; Sun Hui; Wang Xiang-qian; Liang Liu; Wang Xi-jun;

  • 作者单位

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Natl Chinmed Res Ctr Lab Metab Dept Pharmaceut An Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Natl Chinmed Res Ctr Lab Metab Dept Pharmaceut An Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Natl Chinmed Res Ctr Lab Metab Dept Pharmaceut An Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Natl Chinmed Res Ctr Lab Metab Dept Pharmaceut An Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Natl Chinmed Res Ctr Lab Metab Dept Pharmaceut An Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Macau Univ Sci &

    Technol State Key Lab Qual Res Chinese Med Ave Wai Long Taipa Macau Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Natl Chinmed Res Ctr Lab Metab Dept Pharmaceut An Heping Rd 24 Harbin Heilongjiang Peoples R China;

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