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Bio-distribution and bio-availability of silver and gold in rat tissues with silver/gold nanorod administration

机译：银/金纳米棒给药在大鼠组织中银和金的生物分布和生物利用度

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Along with the increasing applications of nanomaterials in medical fields, to know the systemic distribution of nanomaterials in the body through a precise method is required for the biosafety assessment of nanomaterials. In this study, we firstly have established a reliable inductively coupled plasma mass spectrometry (ICP-MS) method for concentration measurement of silver (Ag) and gold (Au) in biological tissues. Then, based on this method, the Ag or Au distribution in rat blood and almost all of the organs were analyzed after an i.v. or?s.c. administration of Au@Ag NRs. Both the time-dependent contents of Ag and Au in blood and two pharmacokinetic models confirmed the rapid clearance of Ag from blood. At 24 h after i.v. injection, there was the highest level of Ag in liver, followed by portal nodes, spleen, lung, bone marrow and pancreas. In addition, we also found there were gender-related distributions of Ag and Au in some organs, especially after s.c. injection. Therefore, these more comprehensive and important results would give fundamental information for the biological risk assessment of nanomaterials.
机译：随着纳米材料在医学领域的日益广泛的应用，通过一种精确的方法来了解纳米材料在人体中的系统分布对于纳米材料的生物安全性评估是必需的。在这项研究中，我们首先建立了一种可靠的电感耦合等离子体质谱法（ICP-MS），用于测量生物组织中银（Ag）和金（Au）的浓度。然后，基于这种方法，静脉内注射后，分析了大鼠血液和几乎所有器官中的Ag或Au分布。或？s.c。 Au @ Ag NRs的管理。血液中Ag和Au的时间依赖性含量以及两个药代动力学模型都证实了Ag从血液中的快速清除。静脉注射后24小时注射后，肝脏中的Ag水平最高，其次是门结，脾脏，肺，骨髓和胰腺。此外，我们还发现某些器官中Ag和Au存在与性别有关的分布，尤其是在南海之后。注射。因此，这些更全面，重要的结果将为纳米材料的生物风险评估提供基础信息。

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