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首页> 外文期刊>RSC Advances >Morin incorporated polysaccharide–protein (psyllium–keratin) hydrogel scaffolds accelerate diabetic wound healing in Wistar rats
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Morin incorporated polysaccharide–protein (psyllium–keratin) hydrogel scaffolds accelerate diabetic wound healing in Wistar rats

机译：Morin掺入的多糖-蛋白质（蚤草-角蛋白）水凝胶支架可加速Wistar大鼠的糖尿病伤口愈合

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Chronic wounds cost several billion dollars of public healthcare spending annually and continue to be a persistent threat globally. Several treatment methods have been explored, and all of them involve covering up the wound with therapeutic dressings that reduce inflammation and accelerate the healing process. In this present study, morin (MOR) was loaded onto hydrogel scaffolds prepared from psyllium seed husk polysaccharide (PSH), and human hair keratins (KER) crosslinked with sodium trimetaphosphate. ATR-FTIR confirmed the presence of the constituent chemical ingredients. SEM images of the scaffold surface reveal a highly porous architecture, with about 80% porosity measured by liquid displacement measurement, irrespective of the morin concentration. Swelling assays carried out on the scaffolds portray an ability to absorb up to seven times their dry weight of fluids. This makes them attractive for guiding moist wound healing on medium exuding wounds. An Alamar blue assay of NIH/3T3 fibroblast cells shows that cell viability decreases in the first 24 h but recovers to 85% in comparison to a control after 48 h. SEM images of fibroblast cells grown on the scaffolds confirm cellular attachment. An in vivo diabetic wound healing study showed that PSH + KER + MOR scaffold treatment significantly reduced the re-epithelialization time (p < 0.01) and enhanced the rate of wound contraction (p < 0.001), by accelerating collagen synthesis in diabetic rats compared to controls.
机译：慢性伤口每年花费数十亿美元的公共医疗保健费用，并且仍然是全球范围内持续存在的威胁。已经探索了几种治疗方法，并且所有方法都涉及用治疗性敷料掩盖伤口，所述治疗性敷料可减轻炎症并加速愈合过程。在本研究中，将茉莉醇（MOR）加载到由车前籽壳皮多糖（PSH）和与三偏磷酸钠交联的人发角蛋白（KER）制备的水凝胶支架上。 ATR-FTIR确认存在化学成分。脚手架表面的SEM图像显示出高度多孔的结构，无论摩尔浓度如何，通过液体位移测量可测出约80％的孔隙率。在脚手架上进行的溶胀试验表明其吸收多达其液体干重的七倍的能力。这使它们对于引导中等渗出伤口的湿润伤口愈合具有吸引力。 NIH / 3T3成纤维细胞的Alamar蓝检测结果显示，与对照组相比，细胞活力在开始的24小时内下降，但在48小时后恢复到85％。生长在支架上的成纤维细胞的SEM图像证实了细胞附着。一项体内糖尿病伤口愈合研究表明，PSH + KER + MOR支架治疗可显着缩短再上皮形成时间（ p <0.01）并提高伤口收缩率（ （ p <0.001），与对照组相比，可加速糖尿病大鼠的胶原蛋白合成。

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