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首页> 外文期刊>RSC Advances >Morin incorporated polysaccharide-protein (psyllium-keratin) hydrogel scaffolds accelerate diabetic wound healing in Wistar rats
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Morin incorporated polysaccharide-protein (psyllium-keratin) hydrogel scaffolds accelerate diabetic wound healing in Wistar rats

机译：Morin掺入多糖 - 蛋白质（psylium-keratin）水凝胶支架在Wistar大鼠中加速糖尿病伤口愈合

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Chronic wounds cost several billion dollars of public healthcare spending annually and continue to be a persistent threat globally. Several treatment methods have been explored, and all of them involve covering up the wound with therapeutic dressings that reduce inflammation and accelerate the healing process. In this present study, morin (MOR) was loaded onto hydrogel scaffolds prepared from psyllium seed husk polysaccharide (PSH), and human hair keratins (KER) crosslinked with sodium trimetaphosphate. ATR-FTIR confirmed the presence of the constituent chemical ingredients. SEM images of the scaffold surface reveal a highly porous architecture, with about 80% porosity measured by liquid displacement measurement, irrespective of the morin concentration. Swelling assays carried out on the scaffolds portray an ability to absorb up to seven times their dry weight of fluids. This makes them attractive for guiding moist wound healing on medium exuding wounds. An Alamar blue assay of NIH/ 3T3 fibroblast cells shows that cell viability decreases in the first 24 h but recovers to 85% in comparison to a control after 48 h. SEM images of fibroblast cells grown on the scaffolds confirm cellular attachment. An in vivo diabetic wound healing study showed that PSH + KER + MOR scaffold treatment significantly reduced the re-epithelialization time (p 0.01) and enhanced the rate of wound contraction (p 0.001), by accelerating collagen synthesis in diabetic rats compared to controls.
机译：慢性伤口每年成本数十亿美元的公共医疗保健支出，并在全球范围内继续持续存在威胁。已经探索了几种治疗方法，所有处理方法都涉及用治疗敷料覆盖伤口，从而减少炎症并加速愈合过程。在本研究中，Morin（Mor）装载到由母氏菌种子壳多糖（PSH）制备的水凝胶支架上，与三磷酸钠交联的人发角蛋白（Ker）。 ATR-FTIR确认存在构成化学成分。支架表面的SEM图像显示出高度多孔的结构，通过液位测量测量约80％的孔隙率，而不管Morin浓度如何。在脚手架上进行的肿胀测定描绘了它们干燥的干重的液体的七倍的能力。这使得它们对于在渗出伤口上引导湿润的伤口愈合具有吸引力。 NIH / 3T3成纤维细胞的Alamar蓝色测定表明，细胞活力在前24小时内降低，但与48小时后的对照相比，恢复为85％。在支架上生长的成纤维细胞的SEM图像确认细胞附着。体内糖尿病伤口愈合研究表明，PSH + ker + Mor支架处理显着降低了再上皮化时间（P <0.01），通过加速糖尿病大鼠中的胶原蛋白合成增强伤口收缩（P <0.001）的速率与控制相比。

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  • 来源
    《RSC Advances》 |2018年第5期|共10页
  • 作者

    Ponrasu Thangavel; Veerasubramanian Praveen Krishna; Kannan Ramya; Gopika Selvakumar; Suguna Lonchin; Muthuvijayan Vignesh;

  • 作者单位

    Indian Inst Technol Bhupat &

    Jyoti Mehta Sch Biosci Dept Biotechnol Madras 600036 Tamil Nadu India;

    Indian Inst Technol Bhupat &

    Jyoti Mehta Sch Biosci Dept Biotechnol Madras 600036 Tamil Nadu India;

    Indian Inst Technol Bhupat &

    Jyoti Mehta Sch Biosci Dept Biotechnol Madras 600036 Tamil Nadu India;

    CSIR Cent Leather Res Inst Dept Biochem Madras 600020 Tamil Nadu India;

    CSIR Cent Leather Res Inst Dept Biochem Madras 600020 Tamil Nadu India;

    Indian Inst Technol Bhupat &

    Jyoti Mehta Sch Biosci Dept Biotechnol Madras 600036 Tamil Nadu India;

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  • 中图分类 化学;
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