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首页> 外文期刊>RSC Advances >Icariin enhances intestinal barrier function by inhibiting NF-κB signaling pathways and modulating gut microbiota in a piglet model
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Icariin enhances intestinal barrier function by inhibiting NF-κB signaling pathways and modulating gut microbiota in a piglet model

机译：通过抑制NF-κB信号通路并调节仔猪模型中的肠道菌群，伊卡瑞林可增强肠屏障功能

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This study investigated the effects of icariin on intestinal barrier function and its underlying mechanisms. The icariin diet improved the growth rate and reduced the diarrhea rate in piglets. The icariin diet also reduced the levels of plasma and colonic IL-1β, -6, -8, TNF-α, and MDA but increased the plasma and colonic activity of SOD, GPx, and CAT. Besides, the levels of plasma and colonic endotoxin, DAO, D -lactate, and zonulin were markedly reduced in icariin groups. Meanwhile, dietary intake icariin significantly increased the gene and protein expression of ZO-1, Occludin, and Claudin-1 in the colon. Furthermore, the gene and protein expressions of TLR4, MyD88, and NF-κB were significantly inhibited in the colon of icariin fed piglets. The intestinal microbiota composition and function was changed by the icariin diet. Collectively, these findings increase our understanding of the mechanisms by which ICA enhances the intestinal barrier function and promotes the development of nutritional intervention strategies.
机译：这项研究调查了大麻素对肠屏障功能及其潜在机制的影响。饲喂蓖麻油精可以提高仔猪的生长速度，减少腹泻率。大麻素饮食还降低了血浆和结肠中IL-1β，-6，-8，TNF-α和MDA的水平，但增加了SOD，GPx和CAT的血浆和结肠活性。此外，在柠檬素组中血浆和结肠内毒素，DAO，D-乳酸和连蛋白的水平显着降低。同时，饮食中摄入的冰ari素显着增加了结肠中ZO-1，Occludin和Claudin-1的基因和蛋白质表达。此外，在饲喂蓖麻油素的仔猪的结肠中，TLR4，MyD88和NF-κB的基因和蛋白质表达受到显着抑制。尿素饮食改变了肠道菌群的组成和功能。总而言之，这些发现增加了我们对ICA增强肠屏障功能并促进营养干预策略发展的机制的理解。

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