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首页> 外文期刊>RSC Advances >Advancing fabrication and properties of three-dimensional graphene–alginate scaffolds for application in neural tissue engineering
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Advancing fabrication and properties of three-dimensional graphene–alginate scaffolds for application in neural tissue engineering

机译：先进的三维石墨烯-海藻酸盐支架的制造和性能，可用于神经组织工程

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Neural tissue engineering provides enormous potential for restoring and improving the function of diseased/damaged tissues and promising opportunities in regenerative medicine, stem cell technology, and drug discovery. The conventional 2D cell cultures have many limitations to provide informative and realistic neural interactions and network formation. Hence, there is a need to develop three-dimensional (3D) bioscaffolds to facilitate culturing cells with matched microenvironment for cell growth and interconnected pores for penetration and migration of cells. Herein, we report the synthesis and characterization of 3D composite bioscaffolds based on graphene-biopolymer with porous structure and improved performance for tissue engineering. A simple, eco-friendly synthetic method is introduced and optimized for synthesis of this hybrid fibrous scaffold by combining Graphene Oxide (GO) and Sodium Alginate (Na-ALG) which are specifically selected to match the mechanical strength of the central nervous system (CNS) tissue and provide porous structure for connective tissue engineering. Properties of the developed scaffold in terms of the structure, porosity, thermal stability, mechanical properties, and electrical conductivity are presented. These properties were optimised through key synthesis conditions including GO concentrations, reduction process and crosslinking time. In contrast to other studies, the presented structure maintains its stability in aqueous media and uses a bio-friendly reducing agent which enable the structure to enhance neuron cell interactions and act as nerve conduits for neurological diseases.
机译：神经组织工程为恢复和改善患病/受损组织的功能提供了巨大的潜力，并且在再生医学，干细胞技术和药物发现方面具有广阔的前景。常规的2D细胞培养具有许多局限性，无法提供信息丰富且逼真的神经相互作用和网络形成。因此，需要开发三维（3D）生物支架，以促进培​​养具有匹配的微环境的细胞以用于细胞生长并且具有互连的孔以用于细胞的渗透和迁移。本文中，我们报告了基于具有多孔结构和改进的组织工程性能的石墨烯-生物聚合物的3D复合生物支架的合成和表征。通过结合专门选择以匹配中枢神经系统（CNS）机械强度的氧化石墨烯（GO）和海藻酸钠（Na-ALG）引入并优化了一种简单，环保的合成方法来合成这种杂化纤维支架）组织并为结缔组织工程提供多孔结构。提出了在结构，孔隙率，热稳定性，机械性能和电导率方面开发的支架的性能。通过关键合成条件（包括GO浓度，还原过程和交联时间）优化了这些性能。与其他研究相反，本发明的结构在水性介质中保持其稳定性，并使用生物友好型还原剂，该还原剂可使该结构增强神经元细胞之间的相互作用并充当神经系统疾病的神经导管。

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