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首页> 外文期刊>RSC Advances >Structural characterization of polysaccharides from Cordyceps militaris and their hypolipidemic effects in high fat diet fed mice
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Structural characterization of polysaccharides from Cordyceps militaris and their hypolipidemic effects in high fat diet fed mice

机译：Cord虫草多糖的结构表征及其在高脂饮食喂养小鼠中的降血脂作用

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Cordyceps militaris is a crude dietary therapeutic mushroom with high nutritional and medicinal values. Mushroom-derived polysaccharides have been found to possess antihyperglycemic and antihyperlipidemic activities. This study aimed to partially clarify the structural characterization and comparatively evaluate hypolipidemic potentials of intracellular- (IPCM) and extracellular polysaccharides of C. militaris (EPCM) in high fat diet fed mice. Results indicated that IPCM-2 is α-pyran polysaccharide with an average molecular weight of 32.5 kDa, was mainly composed of mannose, glucose and galactose with mass percentages of 51.94%, 10.54%, and 37.25%, respectively. EPCM-2 is an α-pyran polysaccharide with an average molecular weight of 20 kDa that is mainly composed of mannose, glucose and galactose with mass percentages of 44.51%, 18.33%, and 35.38%, respectively. In in vivo study, EPCM-1 treatment (100 mg kg ~(?1) d ~(?1) ) showed potential effects on improving serum lipid profiles of hyperlipidemic mice, reflected by decreasing serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) levels by 20.05%, 45.45% and 52.63%, respectively, while IPCM-1 treatment (100 mg kg ~(?1) d ~(?1) ) remarkably decreased TC, TG and LDL-C levels by 20.74%, 47.93%, and 38.25%, respectively. In addition, EPCM-1 ameliorated hyperlipidemia possibly through upregulating the expression of serum lipoprotein lipase (LPL) and down-regulating the expression of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), as determined by enzyme-linked immunosorbent assay (ELISA) method, while IPCM-1 remarkably upregulated the expression of serum LPL. This study confirms polysaccharides from C. militaris could be explored as functional foods or natural medicines for preventing hyperlipidemia.
机译：y虫草是一种具有高营养和药用价值的粗制食用蘑菇。已经发现，蘑菇衍生的多糖具有降血糖和降血脂的活性。这项研究旨在部分阐明结构特征并比较评估高脂饮食喂养小鼠中鱼梭菌的细胞内（IPCM）和细胞外多糖（EPCM）的降血脂潜力。结果表明，IPCM-2为α-吡喃多糖，平均分子量为32.5 kDa，主要由甘露糖，葡萄糖和半乳糖组成，质量百分比分别为51.94％，10.54％和37.25％。 EPCM-2是平均分子量为20kDa的α-吡喃多糖，主要由甘露糖，葡萄糖和半乳糖组成，质量百分比分别为44.51％，18.33％和35.38％。在体内研究中，EPCM-1处理（100 mg kg〜（？1）d〜（？1））显示出对改善高脂血症小鼠血清脂质谱的潜在影响，反映为降低血清总胆固醇（TC），甘油三酸酯（TG） ）和低密度脂蛋白胆固醇（LDL-C）水平分别降低了20.05％，45.45％和52.63％，而IPCM-1处理（100 mg kg〜（？1）d〜（？1））显着降低了TC， TG和LDL-C水平分别降低20.74％，47.93％和38.25％。此外，EPCM-1可能通过上调血清脂蛋白脂酶（LPL）的表达和下调肝3-羟基-3-甲基戊二酰-CoA还原酶（HMGR）的表达来改善高脂血症，如通过酶联免疫吸附法测定的（ELISA）方法，而IPCM-1明显上调血清LPL的表达。这项研究证实，鱼多糖可以作为功能性食品或天然药物来预防高脂血症。

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