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首页> 外文期刊>RSC Advances >Antimicrobial synergy of cationic grafted poly(para-phenylene ethynylene) and poly(para-phenylene vinylene) compounds with UV or metal ions against Enterococcus faecium
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Antimicrobial synergy of cationic grafted poly(para-phenylene ethynylene) and poly(para-phenylene vinylene) compounds with UV or metal ions against Enterococcus faecium

机译：阳离子接枝聚对亚苯基乙炔和聚对亚苯基亚乙烯基化合物与紫外线或金属离子对粪肠球菌的抗菌协同作用

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The rise in multidrug resistant bacteria is an area of growing concern and it is essential to identify new biocidal agents. Cationic grafted compounds were investigated for their antimicrobial properties using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests. Synergy testing was carried out using the compounds in the presence of ultraviolet (UV). Fractional inhibitory concentration (FIC) and fractional bactericidal concentration (FBC) tests were carried out using the cationic molecules in conjunction with metal ion solutions of gold, silver, palladium, platinum, rhodium, titanium, tin, vanadium and molybdenum. Individually, the cationic compounds containing quaternary amines, polyphenylene vinylene (PPV) with long polyacrylate grafts ( PPV- g -PMETAC (HMw)), polyphenylene ethylene (PPE) with long polyacrylate grafts ( PPE- g -PMETAC (HMw)), polyphenylene vinylene (PPV) with short polyacrylate grafts ( PPV- g -PMETAC (LMw)) and polyphenylene ethylene (PPE) with short polyacrylate grafts ( PPE- g -PMETAC (LMw)) were effective against Enterococcus faecium . The most successful compound under UV was PPV- g -PMETAC (HMw). Following the FICs, palladium and rhodium ion solutions caused a synergistic reaction with all four tested compounds. The presence of conjugated bonds in the cationic molecules increased its antimicrobial activity. These results suggest that the chemical backbone of the compounds, alongside the chain lengths and chain attachment affect the antimicrobial efficacy of a compound. These factors should be taken into consideration when formulating new biocidal combinations.
机译：耐多药细菌的增加是一个日益引起人们关注的领域，确定新的杀菌剂至关重要。使用最小抑菌浓度（MIC）和最小杀菌浓度（MBC）测试研究了阳离子接枝化合物的抗菌性能。使用这些化合物在紫外线（UV）存在下进行协同测试。使用阳离子分子，结合金，银，钯，铂，铑，钛，锡，钒和钼的金属离子溶液，进行了分数抑制浓度（FIC）和分数杀菌浓度（FBC）测试。单独地，包含季胺的阳离子化合物，带有长聚丙烯酸酯接枝的聚苯撑乙烯（PPV）（PPV- g -PMETAC（HMw）），带有长聚丙烯酸酯接枝的聚苯乙烯（PPE）（PPE- g -PMETAC（HMw）），聚苯撑带有短聚丙烯酸酯接枝的亚乙烯（PPV）（PPV- g -PMETAC（LMw））和带有短聚丙烯酸酯接枝的聚亚苯基乙烯（PPE）（gw-PMETAC（LMw））对粪肠球菌有效。在紫外线下最成功的化合物是PPV- g -PMETAC（HMw）。在FIC之后，钯和铑离子溶液与所有四种测试化合物产生了协同反应。阳离子分子中共轭键的存在增加了其抗菌活性。这些结果表明，化合物的化学主链以及链长和链附着影响化合物的抗菌功效。在制定新的杀菌组合时，应考虑这些因素。

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