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On the synergy between silver nanoparticles and doxycycline towards the inhibition of Staphylococcus aureus growth

机译：银纳米颗粒与强力霉素对金黄色葡萄球菌生长的抑制作用

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In a previous paper ( RSC Adv. , 2015, 5 , 66886–66893), we showed that the combination of silver nanoparticles (NanoAg) with doxycycline (DO) culminated in an increased bactericidal activity towards E. coli . Herein we further investigated the metabolic changes that occurred on Staphylococcus aureus upon exposure to NanoAg with the help of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) coupled with multivariate data analysis. It has been discovered that the combination of DO with NanoAg produced metabolic changes in S. aureus that were not simply the overlap of the treatments with DO and NanoAg separately. Our results suggest that DO and NanoAg act synergistically to impede protein synthesis by the bacteria.
机译：在先前的论文（RSC Adv。，2015，5，66886-66893）中，我们表明银纳米颗粒（NanoAg）与强力霉素（DO）的结合最终导致对大肠杆菌的杀菌活性增强。本文中，我们通过衰减全反射傅里叶变换红外光谱（ATR-FTIR）结合多变量数据分析，进一步研究了暴露于NanoAg时金黄色葡萄球菌发生的代谢变化。已经发现DO与NanoAg的组合产生了金黄色葡萄球菌的代谢变化，这不仅仅是DO和NanoAg单独处理的重叠。我们的结果表明DO和NanoAg具有协同作用，阻止细菌合成蛋白质。

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