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13-93 bioactive glass/alginate composite scaffolds 3D printed under mild conditions for bone regeneration

机译：在温和条件下3D打印的13-93种生物活性玻璃/海藻酸盐复合支架，可用于骨骼再生

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摘要

Composite scaffolds of type 13-93 bioactive glass (13-93 BG) and sodium alginate (SA), denoted 13-93 BG/SA, in mass ratios of 0?:?4, 1?:?4, 2?:?4 and 4?:?4 were prepared for bone regeneration by 3D printing under mild conditions. All obtained scaffolds were completely interconnected. As the 13-93 BG/SA mass ratio increased from 0?:?4 to 4?:?4, the pore size improved from 340 ± 27 to 530 ± 27 μm, porosity increased from 65.5 ± 5.3 to 87.5 ± 3.9% and shrinkage ratios decreased by half. Moreover, 13-93 BG incorporation improved the compressive strength and modulus of the SA scaffold, achieving highest values of 16.74 ± 1.78 MPa and 79.49 ± 7.38 MPa, respectively, in 13-93 BG/SA with a 2?:?4 mass ratio. Furthermore, in vitro apatite mineralization, the release of bioactive ions (Mg2+ and SiO44?) and a weakly alkaline pH were exhibited by scaffolds containing 13-93 BG, which further promoted the attachment, proliferation and osteogenic differentiation of rBMSCs on composite scaffolds. As a result, 3D-printed 13-93 BG/SA scaffold was an ideal candidate for bone regeneration.
机译：13-93型生物活性玻璃（13-93 BG）和藻酸钠（SA）的复合支架，表示为13-93 BG / SA，质量比为0？：？4、1？：？4、2？：？。在温和的条件下通过3D打印为骨再生制备4和4′∶β4。所有获得的支架都完全互连。当13-93 BG / SA质量比从0？：？4增加到4？：？4时，孔径从340±27增加到530±27μm，孔隙率从65.5±5.3增加到87.5±3.9％，并且收缩率降低了一半。此外，掺入13-93 BG改善了SA支架的抗压强度和模量，在质量比为2？：？4的13-93 BG / SA中，分别达到16.74±1.78 MPa和79.49±7.38 MPa的最高值。 。此外，体外磷灰石矿化，释放出生物活性离子（Mg 2 + 和SiO 4 4？ ）和含有弱碱性pH的13-93 BG支架，进一步促进rBMSCs在复合材料上的附着，增殖和成骨分化脚手架。结果，3D打印的13-93 BG / SA支架是骨骼再生的理想候选者。

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