An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp3)–H bond activation mediated by Selectfluor

Yejun Gao; Robert C. Hider; Yongmin Ma

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An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp3)–H bond activation mediated by Selectfluor

机译：由Selectfluor介导的C（sp3）–H键激活，由苯乙酮和蒽醌合成高效的3-酰基喹啉

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An efficient method for the synthesis of 3-functionalized quinolines from commercially available acetophenones and anthranil has been described. Selectfluor propels the C(sp ~(3) )–H bond activation of the acetophenones and aza-Michael addition of anthranil resulting in annulated 3-acylquinolines in moderate to high yields. DMSO acts not only as a solvent but also as a one carbon donor in the reaction.

机译：已经描述了从市售的苯乙酮和蒽醌合成3-官能化喹啉的有效方法。 Selectfluor推动了苯乙酮的C（sp〜（3））–H键活化和蒽酮的aza-Michael加成反应，从而制得了中度至高产率的环状3-酰基喹啉。 DMSO在反应中不仅充当溶剂，而且充当一个碳供体。

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《RSC Advances》 |2019年第18期|共5页
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Yejun Gao; Robert C. Hider; Yongmin Ma;
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1. An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp(3))-H bond activation mediated by Selectfluor [J] . Gao Yejun, Hider Robert C., Ma Yongmin RSC Advances . 2019,第18期

机译：通过Celedfluor介导的来自苯乙烯酮和蒽醌的高效3-酰基喹啉合成（SP（3）） - H键活化
2. Magnesium-mediated sp3 C–H activation in cascade cyclization of 1-arylethynyl-2-alkyl-o-carboranes: efficient synthesis of carborane-fused cyclopentanes [J] . Jie Zhang, Cen Tang, Zuowei Xie Chemical science . 2020,第36期

机译：1-芳基乙炔基-2-烷基-O-碳钢烷基级联级联的镁介导的SP3 C-H激活：有效合成碳钢环戊烷
3. Activation of sp3 Carbon-Hydrogen Bonds by a Ruthenium(II)Complex and Subsequent Metal-Mediated C-C and C-N Bond Formation [J] . Nicholas A.Foley, T.Brent Gunnoe, Thomas R.Cundari Angewandte Chemie . 2008,第4期

机译：钌（II）络合物对sp3碳氢键的活化作用以及随后的金属介导的C-C和C-N键形成
4. Efficient synthesis of highly funetionalized Indoles and Indolines by C-H bond activation [C] . T. Droge, J. J. Neumann, S. Rakshit European Symposium on Organic Chemistry . 2009

机译：通过C-H键活化有效地合成高浊度吲哚和吲哚吲哚
5. Palladium-mediated carbon-carbon bond formation: Methodology and mechanism. Part I: Palladium-catalyzed alpha-arylation of aryl nitromethanes, phosphonoacetates, and phosphine oxides. Part II: Mechanistic study of the palladium-mediated chemoselective activation of C(sp3)-H bonds. [D] . VanGelder, Kelsey Faith. 2016

机译：钯介导的碳-碳键形成：方法和机理。第一部分：芳族硝基甲烷，膦酰基乙酸酯和氧化膦的钯催化α-芳基化反应。第二部分：钯介导的C（sp3）-H键的化学选择性激活的机理研究。
6. Efficient cleavage of tertiary amide bonds via radical–polar crossover using a copper(ii) bromide/Selectfluor hybrid system [O] . Zhe Wang, Akira Matsumoto, Keiji Maruoka 2020

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7. Homo- and Heteroannulation of sp3 CH Bonds in Acetophenones for Divergent Synthesis of Thienothiazoles [O] . -1

机译：SP3 CH键在苯乙烯酮中的均匀和异位率为Thienothiazoles的发散合成

An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp3)–H bond activation mediated by Selectfluor

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