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首页> 外文期刊>RSC Advances >Molecular-scale structures of the surface and hydration shell of bioinert mixed-charged self-assembled monolayers investigated by frequency modulation atomic force microscopy
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Molecular-scale structures of the surface and hydration shell of bioinert mixed-charged self-assembled monolayers investigated by frequency modulation atomic force microscopy

机译：频率调制原子力显微镜研究生物惰性混合电荷自组装单层表面和水合壳的分子尺度结构

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摘要

We studied the surface structure and hydration structure of a bioinert mix-charged self-assembled monolayer (MC-SAM) comprised of sulfonic acid (SA)- and trimethylamine (TMA)-terminated thiols in liquid by frequency modulation atomic force microscopy (FM-AFM) at a molecular-scale. The TMA end groups showed a highly-ordered rectangular arrangement on a gold substrate in phosphate buffer saline (PBS). Highly structured water was observed at the interface of the MC-SAM and PBS, whereas a less structured hydration structure was observed on bioactive SAMs such as those with OH– and COO– terminal groups. Differences in surface and interface structures between the bioactive and bioinert SAMs suggest that the highly structured water at the bipolar MC-SAM surface works as a physical barrier to prevent adsorption or adhesion of protein and cells. Our results led to the idea that the hydration structure is an important factor in the determination of interactions between SAMs and biomolecules.
机译：我们通过调频原子力显微镜（FM-）研究了液体中由磺酸（SA）-和三甲胺（TMA）封端的硫醇组成的生物惰性混合电荷自组装单层（MC-SAM）的表面结构和水合结构。 AFM）。在磷酸盐缓冲盐水（PBS）中，TMA端基在金基质上显示出高度有序的矩形排列。在MC-SAM和PBS的界面处观察到结构化的水，而在具有OH–和COO–末端基团的生物活性SAM上观察到结构化的水合结构较少。生物活性和生物惰性SAM之间的表面和界面结构差异表明，双极MC-SAM表面的高度结构化水充当物理屏障，可防止蛋白质和细胞的吸附或粘附。我们的结果导致人们认为水合结构是确定SAM与生物分子之间相互作用的重要因素。

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