A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates

Guangyou Jiang; Min Liu; Dongmei Fang; Ping Tan; Min Huang; Taiping Zhou; Zhenju Jiang; Zhihong Xu; Zhouyu Wang

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A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates

机译：一种碱促进的Ramachary还原偶联/烷基化反应的一锅无溶剂版本，用于合成2,2-二取代的氰基乙酸乙酯

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An N , N -diisopropylethylamine promoted solvent-free Ramachary reductive coupling/alkylation (RRC/A) reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates has been developed. A series of 2,2-disubstituted ethyl cyanoacetates were synthesized in one pot by the RRC/A reaction of commercially available aldehydes, ethyl cyanacetates, alkyl halides and Hantzsch ester. A solvent free two step multicomponent reaction has also been developed for the preparation of 2,2-dialkylated malononitriles and 2,2-dialkylated 4-nitrophenyl acetonitriles. All the designed RRC/A products could be easily obtained with good yields by these methods.

机译：已经开发出用于合成2，2-二取代的氰基乙酸乙酯的N，N-二异丙基乙胺促进的无溶剂的Rachachary还原偶联/烷基化（RRC / A）反应。通过市售的醛，氰基乙酸乙酯，烷基卤化物和Hantzsch酯的RRC / A反应，在一个罐中合成了一系列2，2-二取代的氰基乙酸乙酯。还开发了无溶剂的两步多组分反应，用于制备2，2-二烷基化的丙二腈和2，2-二烷基化的4-硝基苯基乙腈。通过这些方法可以很容易地以高收率获得所有设计的RRC / A产品。

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《RSC Advances》 |2018年第16期|共4页
作者
Guangyou Jiang; Min Liu; Dongmei Fang; Ping Tan; Min Huang; Taiping Zhou; Zhenju Jiang; Zhihong Xu; Zhouyu Wang;
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1. A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates [J] . Jiang Guangyou, Liu Min, Fang Dongmei, RSC Advances . 2018,第16期

机译：碱促进了一个罐溶剂自由版本的浆性还原偶联/烷基化反应，用于合成2,2二取代的乙酸乙酯
2. One-pot, Solvent-free Cascade Michael-reductive Cyclization Reaction for the Synthesis of Ethyl 3,5-disubstituted-1H-pyrrole-2-carboxylates Under Microwave Irradiation [J] . Rajni Khajuria, Kamal K. Kapoor Current Microwave Chemistry . 2014,第2期

机译：一锅无溶剂级联迈克尔-还原环化反应在微波辐射下合成3,5-二取代-1H-吡咯-2-羧酸乙酯
3. One-pot synthetic procedure for 2,2 '-disubstituted biaryls via the Suzuki coupling reaction of aryl triflates in a biphasic solvent system [J] . Miura M, Koike T, Ishihara T, Synthetic Communications . 2006,第22a24期

机译：在双相溶剂体系中通过芳基三氟甲磺酸酯的Suzuki偶联反应一锅合成2,2'-二取代的联芳基
4. Multistep Microwave-Assisted Solvent-Free Organic Reactions: Synthesis of 1,6-Disubstituted-4-Oxo-1,4-Dihydro-Pyridine-3-Carboxylic Acid Benzyl Esters [C] . Mauro Panunzio, Maria Antonietta Lentini, Eileen Campana, International Conference on Microwave and High Frequency Heating . 2006

机译：多步微波辅助溶剂有机反应：1,6-二取代-4-氧代-1,4-二氢 - 吡啶-3-羧酸苄基酯的合成
5. THE SYNTHESIS OF THE TRICYCLO(4.2.1.0(3,7)) AND TRICYCLO(4.3.0.0(3,8)) NONANE SYSTEMS AND PREPARATION AND REACTIONS OF 2,2-DISUBSTITUTED TRICYCLO(3.2.1.0(3,6))OCTANES. [D] . DENTZ, BERNARD ISRAEL. 1967

机译：三环（4.2.1.0（3,7））和三环（4.3.0.0（3,8））壬烷体系的合成以及2,2-二取代的三环（3.2.1.0（3,6））的制备和反应大洋洲。
6. The regio- and stereochemical course of reductive cross-coupling reactions between 13-disubstituted allenes and vinylsilanes: Synthesis of (Z)-dienes [O] . Allan U. Barlan, Glenn C. Micalizio -1

机译：13-二取代甲烯和乙烯基硅烷之间的还原交叉偶联反应的测定和立体化学过程：（Z）的合成 - 反应
7. A Green, Solvent-Free One-Pot Synthesis of Disubstituted Quinolines via A3-Coupling Using 1 Mol FeCl3 [O] . Vineet Jeena, Shivani Naidoo 2016

机译：使用1mol％feCl3，通过A3偶联的无二型喹诺网的绿色，无溶剂的单壶合成

A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates

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