A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates

Jiang Guangyou; Liu Min; Fang Dongmei; Tan Ping; Huang Min; Zhou Taiping; Jiang Zhenju; Xu Zhihong; Wang Zhouyu

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A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates

机译：碱促进了一个罐溶剂自由版本的浆性还原偶联/烷基化反应，用于合成2,2二取代的乙酸乙酯

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An N,N-diisopropylethylamine promoted solvent-free Ramachary reductive coupling/alkylation (RRC/A) reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates has been developed. A series of 2,2-disubstituted ethyl cyanoacetates were synthesized in one pot by the RRC/A reaction of commercially available aldehydes, ethyl cyanacetates, alkyl halides and Hantzsch ester. A solvent free two step multicomponent reaction has also been developed for the preparation of 2,2-dialkylated malononitriles and 2,2-dialkylated 4-nitrophenyl acetonitriles. All the designed RRC/A products could be easily obtained with good yields by these methods.

机译：已经开发了N，N-二异丙基乙胺促进的无溶剂的浆性还原偶联/烷基化（RRC / A）对合成2,2-二取代的乙基氰基乙酸酯的反应。通过可商购的醛，乙酸乙酯，烷基卤化物和汉茨基酯的RRC / A反应合成了一系列2,2-二取代的氰基乙酸酯。还开发了一种溶剂两步多组分反应，用于制备2,2-二烷基化丙二腈和2,2-二烷基化的4-硝基苯乙腈。所有设计的RRC / A产品都可以通过这些方法轻松获得良好的产量。

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来源
《RSC Advances》 |2018年第16期|共4页
作者
Jiang Guangyou; Liu Min; Fang Dongmei; Tan Ping; Huang Min; Zhou Taiping; Jiang Zhenju; Xu Zhihong; Wang Zhouyu;
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Xihua Univ Dept Chem Chengdu 610039 Sichuan Peoples R China;

Xihua Univ Dept Chem Chengdu 610039 Sichuan Peoples R China;

Chinese Acad Sci Chengdu Inst Biol Chengdu 610041 Sichuan Peoples R China;

Xihua Univ Dept Chem Chengdu 610039 Sichuan Peoples R China;

Xihua Univ Dept Chem Chengdu 610039 Sichuan Peoples R China;

Xihua Univ Dept Chem Chengdu 610039 Sichuan Peoples R China;

Xihua Univ Dept Chem Chengdu 610039 Sichuan Peoples R China;

Xihua Univ Dept Chem Chengdu 610039 Sichuan Peoples R China;

Xihua Univ Dept Chem Chengdu 610039 Sichuan Peoples R China;

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正文语种 eng
中图分类化学;
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1. A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates [J] . Jiang Guangyou, Liu Min, Fang Dongmei, RSC Advances . 2018,第16期

机译：碱促进了一个罐溶剂自由版本的浆性还原偶联/烷基化反应，用于合成2,2二取代的乙酸乙酯
2. A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates [J] . Guangyou Jiang, Min Liu, Dongmei Fang, RSC Advances . 2018,第16期

机译：一种碱促进的Ramachary还原偶联/烷基化反应的一锅无溶剂版本，用于合成2,2-二取代的氰基乙酸乙酯
3. One-pot, Solvent-free Cascade Michael-reductive Cyclization Reaction for the Synthesis of Ethyl 3,5-disubstituted-1H-pyrrole-2-carboxylates Under Microwave Irradiation [J] . Rajni Khajuria, Kamal K. Kapoor Current Microwave Chemistry . 2014,第2期

机译：一锅无溶剂级联迈克尔-还原环化反应在微波辐射下合成3,5-二取代-1H-吡咯-2-羧酸乙酯
4. Multistep Microwave-Assisted Solvent-Free Organic Reactions: Synthesis of 1,6-Disubstituted-4-Oxo-1,4-Dihydro-Pyridine-3-Carboxylic Acid Benzyl Esters [C] . Mauro Panunzio, Maria Antonietta Lentini, Eileen Campana, International Conference on Microwave and High Frequency Heating . 2006

机译：多步微波辅助溶剂有机反应：1,6-二取代-4-氧代-1,4-二氢 - 吡啶-3-羧酸苄基酯的合成
5. THE SYNTHESIS OF THE TRICYCLO(4.2.1.0(3,7)) AND TRICYCLO(4.3.0.0(3,8)) NONANE SYSTEMS AND PREPARATION AND REACTIONS OF 2,2-DISUBSTITUTED TRICYCLO(3.2.1.0(3,6))OCTANES. [D] . DENTZ, BERNARD ISRAEL. 1967

机译：三环（4.2.1.0（3,7））和三环（4.3.0.0（3,8））壬烷体系的合成以及2,2-二取代的三环（3.2.1.0（3,6））的制备和反应大洋洲。
6. The regio- and stereochemical course of reductive cross-coupling reactions between 13-disubstituted allenes and vinylsilanes: Synthesis of (Z)-dienes [O] . Allan U. Barlan, Glenn C. Micalizio -1

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7. A Green, Solvent-Free One-Pot Synthesis of Disubstituted Quinolines via A3-Coupling Using 1 Mol FeCl3 [O] . Vineet Jeena, Shivani Naidoo 2016

机译：使用1mol％feCl3，通过A3偶联的无二型喹诺网的绿色，无溶剂的单壶合成

A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates

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