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首页> 外文期刊>RSC Advances >A DOX-loaded polymer micelle for effectively inhibiting cancer cells
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A DOX-loaded polymer micelle for effectively inhibiting cancer cells

机译：装有DOX的聚合物胶束可有效抑制癌细胞

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A novel triblock polymer is synthesized and self-assembled with doxorubicin to form DOX-loaded micelles. The synthetic process involves the ring-opening polymerization, carboxylation and amidation reactions, and the structures are characterized. The drug release test indicated that the micelles have the ability to control the release of drugs. The cell uptake results indicated that the DOX-loaded micelles could enter cancer cells easily, and the cytotoxicity and apoptosis test confirmed that DOX-loaded micelles have a strong killing effect on tumor cells, while the blank micelles do not have cytotoxicity. Therefore, the novel polymer micelles are a promising carrier for delivery of anticancer drugs to enhance cancer treatment.
机译：合成了一种新型三嵌段聚合物，并与阿霉素自组装形成了载有DOX的胶束。合成过程涉及开环聚合，羧化和酰胺化反应，并对其结构进行了表征。药物释放试验表明，胶束具有控制药物释放的能力。细胞摄取结果表明，载有DOX的胶束很容易进入癌细胞，并且细胞毒性和凋亡试验证实，载有DOX的胶束对肿瘤细胞有很强的杀伤作用，而空白的胶束则没有细胞毒性。因此，新型聚合物胶束是用于递送抗癌药物以增强癌症治疗的有希望的载体。

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