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A DOX-loaded polymer micelle for effectively inhibiting cancer cells

机译：用于有效抑制癌细胞的DOX加载的聚合物胶束

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摘要

A novel triblock polymer is synthesized and self-assembled with doxorubicin to form DOX-loaded micelles. The synthetic process involves the ring-opening polymerization, carboxylation and amidation reactions, and the structures are characterized. The drug release test indicated that the micelles have the ability to control the release of drugs. The cell uptake results indicated that the DOX-loaded micelles could enter cancer cells easily, and the cytotoxicity and apoptosis test confirmed that DOX-loaded micelles have a strong killing effect on tumor cells, while the blank micelles do not have cytotoxicity. Therefore, the novel polymer micelles are a promising carrier for delivery of anticancer drugs to enhance cancer treatment.
机译：用多柔比蛋白合成新型三嵌段聚合物并自组装以形成DOX加载的胶束。 合成方法涉及开环聚合，羧化和酰胺化反应，并且结构表征。 药物释放试验表明，胶束具有控制药物释放的能力。 细胞吸收结果表明，装载的胶束可以容易进入癌细胞，并且细胞毒性和凋亡试验证实，DOX加载的胶束对肿瘤细胞具有强烈的杀伤作用，而坯料胶束没有细胞毒性。 因此，新型聚合物胶束是一种有望的载体，用于递送抗癌药物以增强癌症治疗。

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  • 来源
    《RSC Advances》 |2018年第46期|共6页
  • 作者

    Feng Huayang; Chu Dandan; Li Zhanrong; Guo Zhihua; Jin Lin; Fan Bingbing; Zhang Junjie; Li Jingguo;

  • 作者单位

    Zhengzhou Univ Peoples Hosp Zhengzhou 450003 Henan Peoples R China;

    Zhengzhou Univ Peoples Hosp Zhengzhou 450003 Henan Peoples R China;

    Zhengzhou Univ Peoples Hosp Zhengzhou 450003 Henan Peoples R China;

    Zhengzhou Univ Peoples Hosp Zhengzhou 450003 Henan Peoples R China;

    Zhengzhou Univ Peoples Hosp Zhengzhou 450003 Henan Peoples R China;

    Zhengzhou Univ Sch Mat Sci &

    Engn Zhengzhou 450003 Henan Peoples R China;

    Zhengzhou Univ Peoples Hosp Zhengzhou 450003 Henan Peoples R China;

    Zhengzhou Univ Peoples Hosp Zhengzhou 450003 Henan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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