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首页> 外文期刊>RSC Advances >Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects
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Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects

机译：对健康受试者口服蜂王浆后中链脂肪酸的代谢和药代动力学

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The unique fatty acids in royal jelly (RJ), 10-hydroxy-2-decenoic acid and 10-hydroxydecanoic acid are expected to be associated with many health benefits, but little is known on the pharmacokinetics and metabolism. The aim of this study is to confirm the metabolism and pharmacokinetics of RJ fatty acids in humans. Twelve volunteers received RJ capsules or enzyme treated RJ (ETRJ) capsules (800 mg). The other group received two doses of ETRJ tablets (800 mg and 1600 mg). Plasma samples were collected up to 12 h after the RJ intake and urine samples were collected within 24 h after ETRJ tablet consumption. The samples were analyzed by LC/MS/MS. A multivariate analysis of the RJ dose plasma samples detected 2-decenedioic acid (2-DA), sebacic acid (SA), and 3-hydroxysebacic acid (3-HSA) with significantly different intensities ( P < 0.05) before and after RJ intake. The area under the concentration (AUC) of 2-DA, SA, and 3-HSA was 2500.05 ± 569.58, 322.57 ± 137.36, and 242.98 ± 58.36 ng h mL ~(?1) , respectively. By enzyme treatment, the AUC of 2-DA, SA, and 3-HSA was significantly increased ( P < 0.05). The values of AUC and urinary excretion of these metabolites were dose-dependent. The major RJ fatty acids were metabolized to dicarboxylate, absorbed into the circulation and their absorption increased by enzyme treatment. This study provides useful information that will support studies aimed at clarifying the identity of bioactive RJ constituents and their biological effect, and further the development of RJ.
机译：蜂王浆（RJ）中的独特脂肪酸，10-羟基-2-癸烯酸和10-羟基癸酸有望带来许多健康益处，但对药代动力学和代谢知之甚少。这项研究的目的是确认RJ脂肪酸在人体中的代谢和药代动力学。 12名志愿者接受了RJ胶囊或酶处理的RJ（ETRJ）胶囊（800毫克）。另一组接受两剂ETRJ片剂（800 mg和1600 mg）。 RJ摄入后至12 h收集血浆样品，ETRJ片剂服用后24 h内收集尿液样品。通过LC / MS / MS分析样品。 RJ剂量血浆样品的多变量分析检测到摄入RJ前后2-癸烯二酸（2-DA），癸二酸（SA）和3-羟基癸二酸（3-HSA）的强度有显着差异（P <0.05） 。 2-DA，SA和3-HSA的浓度下（AUC）面积分别为2500.05±569.58、322.57±137.36和242.98±58.36 ng h mL〜（？1）。通过酶处理，2-DA，SA和3-HSA的AUC显着增加（P <0.05）。这些代谢物的AUC值和尿排泄量是剂量依赖性的。主要的RJ脂肪酸被代谢成二羧酸盐，被吸收到循环系统中，并且通过酶处理增加了它们的吸收。这项研究提供了有用的信息，这些信息将支持旨在阐明生物活性RJ成分的身份及其生物学效应以及进一步发展RJ的研究。

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