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Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects

机译：口服蜂王果冻饲料后中链脂肪酸的代谢和药代动力学

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摘要

The unique fatty acids in royal jelly (RJ), 10-hydroxy-2-decenoic acid and 10-hydroxydecanoic acid are expected to be associated with many health benefits, but little is known on the pharmacokinetics and metabolism. The aim of this study is to confirm the metabolism and pharmacokinetics of RJ fatty acids in humans. Twelve volunteers received RJ capsules or enzyme treated RJ (ETRJ) capsules (800 mg). The other group received two doses of ETRJ tablets (800 mg and 1600 mg). Plasma samples were collected up to 12 h after the RJ intake and urine samples were collected within 24 h after ETRJ tablet consumption. The samples were analyzed by LC/MS/MS. A multivariate analysis of the RJ dose plasma samples detected 2-decenedioic acid (2-DA), sebacic acid (SA), and 3-hydroxysebacic acid (3-HSA) with significantly different intensities (P < 0.05) before and after RJ intake. The area under the concentration (AUC) of 2-DA, SA, and 3-HSA was 2500.05 +/- 569.58, 322.57 +/- 137.36, and 242.98 +/- 58.36 ng h mL(-1), respectively. By enzyme treatment, the AUC of 2-DA, SA, and 3-HSA was significantly increased (P < 0.05). The values of AUC and urinary excretion of these metabolites were dose-dependent. The major RJ fatty acids were metabolized to dicarboxylate, absorbed into the circulation and their absorption increased by enzyme treatment. This study provides useful information that will support studies aimed at clarifying the identity of bioactive RJ constituents and their biological effect, and further the development of RJ.
机译：预计皇家果冻（RJ），10-羟基-2-癸烯酸和10-羟基癸酸和10-羟基二癸酸的独特脂肪酸预计与许多健康益处有关，但在药代动力学和代谢上众所周知。本研究的目的是确认人类RJ脂肪酸的代谢和药代动力学。 12岁志愿者接受了RJ胶囊或酶处理的RJ（ETRJ）胶囊（800mg）。其他组接受了两剂的EtRJ片（800mg和1600mg）。在EtRJ片剂消耗后24小时内收集RJ进气和尿液样品，在etrj片剂消耗后24小时内收集等离子体样品。通过LC / MS / MS分析样品。在RJ摄入前后，RJ剂量等离子体样品对RJ剂量等离子体样品检测到2-二苯甲酸（2-DA），Sebacic酸（SA）和3-羟基丙酸（3-HSA）的显着不同的强度（P <0.05） 。 2 -DA，SA和3-HSA的浓度（AUC）下的区域分别为2500.05 +/- 569.58,222.57 +/-137.36和242.98 +/- 58.36 ng h ml（-1）。通过酶处理，2-DA，SA和3-HSA的AUC显着增加（P <0.05）。这些代谢物的AUC和尿排泄的值依赖于剂量。将主要的RJ脂肪酸代谢为二羧酸盐，吸收到循环中，并通过酶处理增加它们的吸收。本研究提供了有用的信息，可以支持旨在澄清生物活跃的RJ成分的身份及其生物学效应的认可，进一步发展RJ。

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  • 来源
    《RSC Advances》 |2019年第27期|共10页
  • 作者

    Yamaga Masayuki; Tani Hiroko; Yamaki Ayanori; Tatefuji Tomoki; Hashimoto Ken;

  • 作者单位

    Yamada Bee Co Inc Inst Bee Prod &

    Hlth Sci 194 Ichiba Kagamino Okayama Japan;

    Yamada Bee Co Inc Inst Bee Prod &

    Hlth Sci 194 Ichiba Kagamino Okayama Japan;

    Yamada Bee Co Inc Inst Bee Prod &

    Hlth Sci 194 Ichiba Kagamino Okayama Japan;

    Yamada Bee Co Inc Inst Bee Prod &

    Hlth Sci 194 Ichiba Kagamino Okayama Japan;

    Yamada Bee Co Inc Inst Bee Prod &

    Hlth Sci 194 Ichiba Kagamino Okayama Japan;

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