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首页> 外文期刊>RSC Advances >Stratum corneum lipid liposomes for investigating skin penetration enhancer effects
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Stratum corneum lipid liposomes for investigating skin penetration enhancer effects

机译：角质层脂质脂质体用于研究皮肤渗透促进剂的作用

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Knowledge of the mechanism of action of skin penetration enhancers is essential to formulators for optimizing formulations and to maximize the efficacy of enhancers. To obtain information about the effects of penetration enhancers as a fast initial screening, investigations have been performed to identify possible correlations of the biological effectiveness of penetration enhancers with their interaction with a well-defined model system consisting of skin mimic lipid bilayers, as determined by calcein release experiments using stratum corneum lipid liposomes (SCLLs). We aimed to investigate the enhancing effects of different concentrations of two chemical penetration enhancers, Kolliphor RH40 and Transcutol on SCLLs. The results obtained by SCLL-based techniques were compared with conventional ex vivo penetration studies in case of Kolliphor RH40 to evaluate the potential of SCLLs as an alternative tool for screening various types and concentrations of penetration enhancers. As a result, calcein leakage assay performed with SCLL was considered to be a good model for the skin penetration enhancing effect. This method could be used as a time-saving and sensitive alternative in vitro screening technique in the early stage of the development of dermal formulations.
机译：皮肤渗透促进剂作用机理的知识对于配方设计师优化配方和使增强剂的功效最大化至关重要。为了获得有关渗透促进剂作用的信息作为快速的初步筛查，已经进行了研究，以确定渗透促进剂的生物学有效性与其与由皮肤模拟脂质双层构成的定义明确的模型系统相互作用的可能相关性，方法如下：使用角质层脂质脂质体（SCLL）进行钙黄绿素释放实验。我们旨在研究不同浓度的两种化学渗透促进剂Kolliphor RH40和Transcutol对SCLL的增强作用。将基于SCLL的技术获得的结果与传统的体外渗透研究（在Kolliphor RH40的情况下）进行比较，以评估SCLL作为筛选各种类型和浓度的渗透促进剂的替代工具的潜力。结果，用SCLL进行的钙黄绿素泄漏测定被认为是增强皮肤渗透效果的良好模型。在皮肤制剂开发的早期阶段，该方法可用作省时且灵敏的替代性体外筛选技术。

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