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Synthesis and characterization of tannic acid–PEG hydrogel via Mitsunobu polymerization

机译：通过Mitsunobu聚合反应合成鞣酸-PEG水凝胶

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摘要

Tannic acid (TA) based materials have received significant interest owing to their broad spectrum of chemical and biological properties. Herein, a novel tannic acid based hydrogel, TA–PEG hydrogel, was synthesized via Mitsunobu polymerization/polycondensation, in which TA and polyethylene glycol (PEG) were simply crosslinked together by ether linkages. This method was performed in one pot, straightforward, metal free and robust, ignoring the strong ionic/hydrophobic interactions between tannic acid and PEG. Bearing catechol and pyrogallol units from TA, TA–PEG hydrogel did not only reduce the silver and gold precursor, but also served as a capping agent and stabilizer for the in situ formed Au and Ag nanoparticles (NPs). Furthermore, the antioxidant activity of the hydrogel was excellent (94%) in the case of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging. TA–PEG hydrogel also showed antibacterial activity against Staphylococcus aureus and Escherichia coli . This work suggested a new method leading to polyphenol based soft materials rather than a complex coacervated microstructure. The resulting TA–PEG hydrogel has potential application in biomedical materials.
机译：基于单宁酸（TA）的材料因其广泛的化学和生物学特性而受到广泛关注。本文中，通过Mitsunobu聚合/缩聚反应合成了一种基于单宁酸的新型水凝胶TA-PEG水凝胶，其中TA和聚乙二醇（PEG）通过醚键简单地交联在一起。该方法在一个罐中进行，操作简单，无金属且坚固耐用，而忽略了鞣酸和PEG之间强烈的离子/疏水相互作用。 TA-PEG水凝胶带有来自TA的邻苯二酚和邻苯三酚单元，不仅还原了银和金的前体，而且还充当了原位形成的Au和Ag纳米颗粒（NPs）的封端剂和稳定剂。此外，在清除1，1-二苯基-2-吡啶并肼基（DPPH）自由基的情况下，水凝胶的抗氧化活性极好（94％）。 TA-PEG水凝胶还显示出对金黄色葡萄球菌和大肠杆菌的抗菌活性。这项工作提出了一种新方法，该方法可产生基于多酚的软材料，而不是复杂的凝聚微结构。所得的TA-PEG水凝胶在生物医学材料中具有潜在的应用。

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