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首页> 外文期刊>The journal of immunology >Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming
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Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming

机译：活化的NKT细胞可以调节不同的脾树突状细胞亚群，从而更有效地响应TLR参与并增强交叉引物

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The function of dendritic cells (DCs) can be modulated through multiple signals, including recognition of pathogen-associated molecular patterns, as well as signals provided by rapidly activated leukocytes in the local environment, such as innate-like T cells. In this article, we addressed the possibility that the roles of different murine DC subsets in cross-priming CD8+ T cells can change with the nature and timing of activatory stimuli. We show that CD8α+ DCs play a critical role in cross-priming CD8+ T cell responses to circulating proteins that enter the spleen in close temporal association with ligands for TLRs and/or compounds that activate NKT cells. However, if NKT cells are activated first, then CD8α? DCs become conditioned to respond more vigorously to TLR ligation, and if triggered directly, these cells can also contribute to priming of CD8+ T cell responses. In fact, the initial activation of NKT cells can condition multiple DC subsets to respond more effectively to TLR ligation, with plasmacytoid DCs making more IFN-α and both CD8α+ and CD8α? DCs manufacturing more IL-12. These results suggest that different DC subsets can contribute to T cell priming if provided appropriately phased activatory stimuli, an observation that could be factored into the design of more effective vaccines.
机译：树突状细胞（DCs）的功能可以通过多种信号进行调节，包括识别病原体相关的分子模式，以及在局部环境中快速激活的白细胞（如先天性T细胞）提供的信号。在本文中，我们探讨了交叉启动CD8 + T细胞中不同鼠DC亚群的作用可能随激活性刺激的性质和时间而改变的可能性。我们显示，CD8α+ DCs在交叉引发CD8 + T细胞对循环进入脾脏的循环蛋白的反应中起着至关重要的作用，与TLRs和/或激活NKT细胞的化合物的配体紧密时间相关。但是，如果首先激活NKT细胞，那么CD8α？ DCs适应了更强烈地响应TLR连接的条件，如果直接触发，这些细胞也可能有助于引发CD8 + T细胞反应。实际上，NKT细胞的初始激活可以调节多个DC亚群以更有效地响应TLR连接，而浆细胞样DC则产生更多的IFN-α以及CD8α+和CD8α？ DC制造更多的IL-12。这些结果表明，如果提供适当的阶段性活化刺激，则不同的DC亚群可以促进T细胞的启动，这一观察结果可以被认为是设计更有效的疫苗的因素。

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