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首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming
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Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming

机译：活化的NKT细胞可以调节不同的脾性树突状细胞亚群，从而更有效地响应TLR参与并增强交叉激活

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摘要

The function of dendritic cells (DCs) can be modulated through multiple signals, including recognition of pathogen-associated molecular patterns, as well as signals provided by rapidly activated leukocytes in the local environment, such as innate-like T cells. In this article, we addressed the possibility that the roles of different murine DC subsets in cross-priming CD8(+) T cells can change with the nature and timing of activatory stimuli. We show that CD8 alpha(+) DCs play a critical role in cross-priming CD8(+) T cell responses to circulating proteins that enter the spleen in close temporal association with ligands for TLRs and/or compounds that activate NKT cells. However, if NKT cells are activated first, then CD8 alpha(-) DCs become conditioned to respond more vigorously to TLR ligation, and if triggered directly, these cells can also contribute to priming of CD8(+) T cell responses. In fact, the initial activation of NKT cells can condition multiple DC subsets to respond more effectively to TLR ligation, with plasmacytoid DCs making more IFN-alpha and both CD8 alpha(+) and CD8 alpha(-) DCs manufacturing more IL-12. These results suggest that different DC subsets can contribute to T cell priming if provided appropriately phased activatory stimuli, an observation that could be factored into the design of more effective vaccines.
机译：树突状细胞（DCs）的功能可以通过多种信号进行调节，包括识别病原体相关的分子模式，以及在局部环境中快速激活的白细胞（如先天性T细胞）提供的信号。在本文中，我们探讨了交叉启动CD8（+）T细胞中不同鼠DC亚组的作用可能随激活性刺激的性质和时间而变化的可能性。我们显示，CD8 alpha（+）DC在交叉引发CD8（+）T细胞对进入脾脏的循环蛋白中的关键作用中起着至关重要的作用，与TLRs和/或激活NKT细胞的化合物的配体紧密时间相关。但是，如果先激活NKT细胞，则CD8 alpha（-）DC会变得条件更强，对TLR连接反应更强，并且如果直接触发，这些细胞也可能有助于引发CD8（+）T细胞反应。实际上，NKT细胞的初始激活可以调节多个DC亚群以更有效地响应TLR连接，浆细胞样DC产生更多的IFN-α，CD8 alpha（+）和CD8 alpha（-）产生更多的IL-12。这些结果表明，如果提供适当的阶段性活化刺激，则不同的DC亚群可以促进T细胞的启动，这一观察结果可以被认为是设计更有效的疫苗的因素。

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