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首页> 外文期刊>World Journal of Gastroenterology >Sequential blood purification therapy for critical patients with hyperlipidemic severe acute pancreatitis
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Sequential blood purification therapy for critical patients with hyperlipidemic severe acute pancreatitis

机译：序贯血液净化治疗重症高脂血症性重症急性胰腺炎患者

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AIM: To evaluate the efficacy of sequential blood purification therapy in the treatment of critical patients with hyperlipidemic severe acute pancreatitis. METHODS: Thirty-one intensive care unit (ICU) patients with hyperlipidemic severe acute pancreatitis treated at the Second Affiliated Hospital of Harbin Medical University were divided into either a study group (n = 15; July 1, 2012 to June 30, 2014) or a control group (n = 16; July 1, 2010 to June 30, 2012) based on the implementation of sequential blood purification therapy. The control group received continuous venous-venous hemofiltration (CVVH) on the basis of conventional treatments, and the therapeutic dose of CVVH was 30 mL/kg per hour. The study group received sequential plasma exchange and CVVH on the basis of conventional treatments. The anticoagulation regimen of CVVH is the regional citrate anticoagulation. Mortality rate on day 28, rates of systemic and local complications, duration of ICU, and time to target serum lipid level, as well as physiologic and laboratory indices were compared between the two groups. RESULTS: The mortality rate on day 28 was significantly lower in the study group than in the control group (13.33% vs 37.50%; P vs 9.19 ± 2.99 d, P vs 7.90 ± 1.14 d, P vs 50% and 80% vs 81%, respectively). In the comparisons of physiologic and laboratory indices, serum albumin and C-reactive protein were significantly better in the study group than in the control group after treatment (37.8 ± 4.6 g/L vs 38.9 ± 5.7 g/L, and 20.5 ± 6.4 mg/L vs 28.5 ± 7.1 mg/L, respectively, both P CONCLUSION: Sequential blood purification therapy is effective in the treatment of ICU patients with hyperlipidemic severe acute pancreatitis and can improve patient prognosis.
机译：目的：评估序贯血液净化治疗在高脂血症性重症急性胰腺炎危重患者中的疗效。方法：将哈尔滨医科大学第二附属医院收治的高脂血症性重症急性胰腺炎重症监护病房（ICU）31例分为研究组（n = 15; 2012年7月1日至2014年6月30日）或对照组（n = 16; 2010年7月1日至2012年6月30日）基于序贯血液净化疗法的实施。对照组在常规治疗的基础上接受连续静脉-静脉血液滤过（CVVH），CVVH的治疗剂量为每小时30 mL / kg。研究组在常规治疗的基础上接受了顺序血浆置换和CVVH。 CVVH的抗凝方案是局部柠檬酸盐抗凝。比较两组的第28天死亡率，全身和局部并发症发生率，ICU持续时间，达到目标血脂水平的时间以及生理和实验室指标。结果：研究组第28天的死亡率显着低于对照组（13.33％vs 37.50％; P vs 9.19±2.99 d，P vs 7.90±1.14 d，P vs 50％和80％vs 81 ％， 分别）。在生理和实验室指标的比较中，治疗后研究组的血清白蛋白和C反应蛋白明显优于对照组（37.8±4.6 g / L vs 38.9±5.7 g / L和20.5±6.4 mg / L vs. 28.5±7.1 mg / L，两者均P结论：序贯血液净化治疗对ICU高脂血症性重症急性胰腺炎患者有效，可改善患者的预后。

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