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首页> 外文期刊>World Journal of Gastroenterology >Gender differences in ghrelin, nociception genes, psychological factors and quality of life in functional dyspepsia
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Gender differences in ghrelin, nociception genes, psychological factors and quality of life in functional dyspepsia

机译：生长激素释放激素，伤害感受基因，心理因素和功能性消化不良生活质量的性别差异

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AIM to evaluate gender differences in the aspect of ghrelin, nociception-related genes and psychological aspects and the quality of life (QoL) in Korean functional dyspepsia (FD) patients. METHODS Total of 191 persons were prospectively enrolled between March 2013 and May 2016 in Seoul National Bundang Hospital, and classified into control and FD group based on ROME III criteria. Questionnaire included assessment for dyspepsia symptoms, QoL and anxiety or depression. Preproghrelin and nociception genes in the gastric mucosa and plasma acyl/des-acyl ghrelin were measured. RESULTS Lower level of plasma acyl ghrelin in FD patients compared to control was significant only in male (15.9 fmol/mL vs 10.4 fmol/mL, P = 0.017). Significantly higher mRNA expressions of nerve growth factor and transient receptor potential vanilloid receptor 1 were observed in male ( P = 0.002 and P = 0.014, respectively) than in female. In contrast, female FD patients had a higher anxiety and depression score than male FD ( P = 0.029), and anxiety score was correlated with epigastric pain only in female FD patients (female: Spearman rho = 0.420, P = 0.037). The impairment of overall QoL was more prominent in female FD patients than male patients (5.4 ± 0.3 vs 6.5 ± 0.3, P = 0.020). CONCLUSION Gender differences of ghrelin and nociception-related genes in male and psychological factors in female underlie FD symptoms. More careful assessment of psychological or emotional status is required particularly for the female FD patients.
机译：目的评估韩国功能性消化不良（FD）患者的生长素释放肽，伤害感受相关基因和心理方面以及生活质量（QoL）方面的性别差异。方法于2013年3月至2016年5月在首尔国立邦当医院共纳入191人，根据ROME III标准分为对照组和FD组。问卷包括对消化不良症状，生活质量和焦虑或抑郁的评估。测量了胃粘膜和血浆酰基/去酰基胃饥饿素中的前促胃泌素和伤害感受基因。结果FD患者血浆酰基生长素释放肽水平低于对照组，仅在男性中显着（15.9 fmol / mL对10.4 fmol / mL，P = 0.017）。男性中神经生长因子和瞬时受体电位类香草受体1的mRNA表达明显高于女性（分别为P = 0.002和P = 0.014）。相反，女性FD患者的焦虑和抑郁评分高于男性FD（P = 0.029），而焦虑评分仅与女性FD患者的上腹痛相关（女性：Spearman rho = 0.420，P = 0.037）。女性FD患者的总体QoL损害比男性患者更为突出（5.4±0.3 vs 6.5±0.3，P = 0.020）。结论FD症状是男性中ghrelin和伤害感受相关基因的性别差异以及女性的心理因素。特别是女性FD患者，需要对心理或情绪状态进行更仔细的评估。

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