Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development

Kristy L. Kenyon; Donghui Yang-Zhou; Chuan Qi Cai; Susan Tran; Chris Clouser; Gina Decene; Swati Ranade; Francesca Pignoni

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Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development

机译：伙伴特异性对于蝇眼发育过程中SIX型同源域蛋白Sine oculis和Optix的正常功能至关重要

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ThedevelopmentoftheemDrosophila/emvisualsystemutilizestwomembersofthehighlyconservedSix-Homeoboxfamilyoftranscriptionfactor,SineoculisandOptix.AlthoughinvitrostudieshavedetecteddifferencesinDNA-bindingandinteractionswithsomeco-factors,questionsremainastowhatextenttheactivityforthesetwotranscriptionalregulatorsisredundantorspecificinvivo.Inthiswork,weshowthattheSosupD/supmutationwithintheSixdomaindoesnotabolishDNAndash;proteininteractions,butaltersco-factorbindingspecificitytoresemblethatofOptix.AmutationinthesameregionofOptixaltersitsactivityinvivo.WeproposethatthedominantmutantphenotypeisprimarilyduetoanalterationinbindingpropertiesoftheSineoculisproteinandthatdistinctpartnerinteractionsisoneimportantmechanismindeterminingsignificantfunctionaldifferencesbetweenthesehighlyconservedfactorsduringeyedevelopment./p/div

机译：Thedevelopmentofthe 果蝇 visualsystemutilizestwomembersofthehighlyconservedSix-Homeoboxfamilyoftranscriptionfactor，SineoculisandOptix.AlthoughinvitrostudieshavedetecteddifferencesinDNA-bindingandinteractionswithsomeco因子，questionsremainastowhatextenttheactivityforthesetwotranscriptionalregulatorsisredundantorspecificinvivo.Inthiswork，weshowthattheSo ^{d mutationwithintheSixdomaindoesnotabolishDNAndash; proteininteractions，butaltersco-factorbindingspecificitytoresemblethatofOptix.AmutationinthesameregionofOptixaltersitsactivityinvivo.WeproposethatthedominantmutantphenotypeisprimarilyduetoanalterationinbindingpropertiesoftheSineoculisproteinandthatdistinctpartnerinteractionsisoneimportantmechanismindeterminingsignificantfunctionaldifferencesbetweenthesehighlyconservedfactorsduringeyedevelopment} 展开▼

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《Developmental biology》 |2005年第1期|共页

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Kristy L. Kenyon; Donghui Yang-Zhou; Chuan Qi Cai; Susan Tran; Chris Clouser; Gina Decene; Swati Ranade; Francesca Pignoni;
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中图分类生物科学;

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1. Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development. [J] . Kenyon KL, Yang Zhou D, Cai CQ, Developmental biology . 2005,第1期

机译：伙伴特异性对于蝇眼发育过程中SIX型同源域蛋白Sine oculis和Optix的正常功能至关重要。

2. Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. [J] . Kenyon KL, Li DJ, Clouser C, Developmental dynamics: an official publication of the American Association of Anatomists . 2005,第3期

机译：飞行SIX型同源域蛋白Sine oculis和Optix在眼睛发育过程中与不同的辅因子结合。

3. Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila. [J] . Niimi T, Seimiya M, Kloter U, Development . 1999,第10期

机译：果蝇眼诱导过程中，无眼蛋白与正弦耳基因中眼特异性增强子的直接调节相互作用。

4. A pollen-specific calmodulin-binding protein from rice is essential to pollen development [C] . Qiusheng Zhang, Zhong Li, Jing Yang, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：水稻花粉特有的钙调蛋白结合蛋白对于花粉发育至关重要

5. Binding Partners Regulate Eyes Absent-Sine Oculis Transcriptional Output during Retinal Development in Drosophila Melanogaster. [D] . Davis, Trevor Lewis. 2017

机译：在果蝇的视网膜发育过程中，结合配偶调节眼睛缺席正弦眼的转录输出。

6. Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster [O] . Barbara Jusiak, Feng Wang, Umesh C. Karandikar, 2014

机译：果蝇的发育眼中同源域转录因子Sine oculis（So）的全基因组DNA结合模式

7. Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development [O] . Kenyon Kristy L., Yang-Zhou Donghui, Cai Chuan Qi, 2005

机译：伙伴特异性对于蝇眼发育过程中SIX型同源域蛋白Sine oculis和Optix的正常功能至关重要

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Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development

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