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首页> 外文期刊>Developmental dynamics: an official publication of the American Association of Anatomists >Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development.
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Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development.

机译：飞行SIX型同源域蛋白Sine oculis和Optix在眼睛发育过程中与不同的辅因子结合。

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摘要

Two members from the Six class of homeobox transcription factors, Sine oculis (SO) and Optix, function during development of the fly visual system. Differences in gain-of-function phenotypes and gene expression suggest that these related factors play distinct roles in the formation of the fly eye. However, the molecular nature of their functional differences remains unclear. In this study, we report the identification of two novel factors that participate in specific partnerships with Sine oculis and Optix during photoreceptor neurons formation and in eye progenitor cells. This work shows that different cofactors likely mediate unique functions of Sine oculis and Optix during the development of the fly eye and that the repeated requirement for SO function at multiple stages of eye development reflects the activity of different SO-cofactor complexes.
机译：六类同源盒转录因子中的两个成员，正弦球（SO）和Optix，在飞行视觉系统的发育过程中发挥作用。功能获得表型和基因表达的差异表明这些相关因素在蝇眼的形成中起着不同的作用。但是，它们功能差异的分子性质仍不清楚。在这项研究中，我们报告了在光感受器神经元形成过程中和眼祖细胞中参与与正弦和视神经的特定伙伴关系的两个新因素的鉴定。这项工作表明，在蝇眼发育过程中，不同的辅助因子可能介导正弦耳和Optix的独特功能，并且在眼睛发育的多个阶段对SO功能的重复要求反映了不同的SO-辅因子复合物的活性。

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