Regulation of mouse oocyte meiotic maturation: Implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis☆

Richard M. Schultz; Ruth R. Montgomery; Jeffrey R. Belanoff

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Regulation of mouse oocyte meiotic maturation: Implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis☆

机译：小鼠卵母细胞减数分裂成熟的调控：卵母细胞cAMP的降低和蛋白质去磷酸化对恢复减数分裂的承诺☆

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MouseoocytesarereversiblyinhibitedfromresumingmeioticmaturationinvitrobycAMPphosphodiesteraseinhibitorssuchas3-isobutyl-1-methylxanthine(IBMX)andcAMPanalogssuchasdibutyrylcAMP(dbcAMP).OocytesculturedinIBMX-containingmediumweretransferredtoandculturedinIBMX-freemediumforvariousperiodsoftimepriortotheirreturntoeitherIBMX-ordbcAMP-containingmedium.Resultsfromtheseexperimentsdefinedaperiodoftimeinwhichoocytesbecamecommittedtoresumingmeiosis.Forskolin,whichelevatedtheintracellularoocytecAMPconcentration,transientlyinhibitedoocytesfromresumingmeiosis.LevelsofcAMPweredeterminedinoocytesincubatedinmediumthatallowsresumptionofmeiosis.ThelevelofoocytecAMPdecreasedsignificantlyduringthetimeinwhichoocytesbecomecommittedtoresumingmeiosis.ThisdecreaseinoocytecAMPwasnotobservedinoocytesinhibitedfromresumingmeiosisbyIBMX.Inaddition,cAMPlevelsweredeterminedinpreovulatoryantralfollicles,cumuluscell-oocytecomplexes,andoocytesduringgonadotropin-inducedresumptionofmeiosisinvivo.AdecreaseinoocytecAMPprecededresumptionofmeiosisasmanifestedbygerminalvesiclebreakdown(GVBD).ThisdecreaseapparentlyoccurredbeforeorduringaperiodoftimeinwhichfollicleandcumuluscellcAMPwereincreasing.AssociatedwithcommitmenttoresumemeiosiswasacharacteristicsetofchangesinoocytephosphoproteinmetabolismthatprecededGVBD.Thesechangesare,todate,someofthefirstreportedbiochemicalchangesthatprecedeGVBD.ResultsfromtheseexperimentsarediscussedintermsofapossiblerolecAMPmayplayinregulationofresumptionofmeiosisinmammals.

机译：MouseoocytesarereversiblyinhibitedfromresumingmeioticmaturationinvitrobycAMPphosphodiesteraseinhibitorssuchas3异丁基-1-甲基黄嘌呤（IBMX）andcAMPanalogssuchasdibutyrylcAMP（dbcAMP）.OocytesculturedinIBMX-containingmediumweretransferredtoandculturedinIBMX-freemediumforvariousperiodsoftimepriortotheirreturntoeitherIBMX-ordbcAMP-containingmedium.Resultsfromtheseexperimentsdefinedaperiodoftimeinwhichoocytesbecamecommittedtoresumingmeiosis.Forskolin，whichelevatedtheintracellularoocytecAMPconcentration，transientlyinhibitedoocytesfromresumingmeiosis.LevelsofcAMPweredeterminedinoocytesincubatedinmediumthatallowsresumptionofmeiosis.ThelevelofoocytecAMPdecreasedsignificantlyduringthetimeinwhichoocytesbecomecommittedtoresumingmeiosis.ThisdecreaseinoocytecAMPwasnotobservedinoocytesinhibitedfromresumingmeiosisbyIBMX.Inaddition，cAMPlevelsweredeterminedinpreovulatoryantralfollicles，cumuluscell-oocytecomplexes，andoocytesduringgonadotropin-inducedresumptionofmeiosisinvivo .AdecreaseinoinocytocAMPprecede dresumptionofmeiosisasmanifestedbygerminalvesiclebreakdown（GVBD）.ThisdecreaseapparentlyoccurredbeforeorduringaperiodoftimeinwhichfollicleandcumuluscellcAMPwereincreasing.AssociatedwithcommitmenttoresumemeiosiswasacharacteristicsetofchangesinoocytephosphoproteinmetabolismthatprecededGVBD.Thesechangesare，TODATE，someofthefirstreportedbiochemicalchangesthatprecedeGVBD.ResultsfromtheseexperimentsarediscussedintermsofapossiblerolecAMPmayplayinregulationofresumptionofmeiosisinmammals。

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《Developmental biology》 |1983年第2期|共页
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Richard M. Schultz; Ruth R. Montgomery; Jeffrey R. Belanoff;
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1. Involvement of cAMP-dependent protein kinase and protein phosphorylation in regulation of mouse oocyte maturation☆ [J] . Elayne A. Bornslaeger, Peter Mattei, Richard M. Schultz Developmental biology . 1986,第2期

机译：cAMP依赖性蛋白激酶和蛋白磷酸化参与小鼠卵母细胞成熟的调控☆
2. Regulation of meiotic metaphase by a cytoplasmic maturation-promoting factor during mouse oocyte maturation☆ [J] . Naohiro Hashimoto, Takeo Kishimoto Developmental biology . 1988,第2期

机译：小鼠卵母细胞成熟过程中细胞质成熟促进因子对减数分裂中期的调控☆
3. Nitric oxide (NO) inhibition of meiotic G2-M1 transition in Anabas testudineus oocytes: Participation of cAMP-dependent protein kinase (PKA) in regulation of intra-oocyte signaling events [J] . Nath Poulomi, Das Debabrata, Pal Soumojit, Molecular and Cellular Endocrinology . 2018,第3期

机译：一氧化氮（NO）抑制减数分裂的G2-M1转变在AnaBas Testudineus卵母细胞中：营养依赖性蛋白激酶（PKA）参与卵母细胞信号传导事件的调节
4. Effect of Dfbutyryl-Camp (Dbc-AMP) and Follicle Stimulation Hormone (FSH) on Meiotic Competence of Porcine Oocytes Dyring In Vitro Matyration and Fertilization [C] . N.T. Thuy-Van, P.T. Duy, T.B. An International Conference on the Development of Biomedical Engineering in Vietnam . 2018

机译：DFBUTYRYL-CAMP（DBC-AMP）和卵泡刺激激素（FSH）对猪卵母细胞大豆卵母细胞大豆菌和施肥的影响
5. Ovine Oocyte in vitro Maturation: effect of cAMP modulation on meiotic progression and developmental competence of sheep IVM oocytes [D] . Buell, Margaret 2011

机译：绵羊卵母细胞体外成熟：cAMP调节对绵羊IVM卵母细胞减数分裂进程和发育能力的影响
6. Microtubule mediation of cytoplasmic and nuclear maturation during the early stages of resumed meiosis in cultured mouse oocytes. [O] . J Van Blerkom 1991

机译：在培养的小鼠卵母细胞恢复减数分裂的早期阶段微管介导的细胞质和核成熟。
7. Induction and Inhibition of Meiotic Maturation in Follicle-enclosed Mouse Oocytes by Forskolin. (meiotic maturation/luteinizing hormone/forskolin/cAMP/mouse oocyte) [O] . NAOHIRO HASHIMOTO, TAKEO KISHIMOTO, YOSHITAKA NAGAHAMA 1985

机译：用FORSKOLIN诱导和抑制卵泡封闭小鼠卵母细胞中的减数分裂。（减数分裂效果/叶氏素激素/ Forskolin / CAMP / MOUS oOcyte）

Regulation of mouse oocyte meiotic maturation: Implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis☆

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