Monoclonal antibodies specific for dengue virus type 3.

D Dittmar; H G Haines; A Castro

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Monoclonal antibodies specific for dengue virus type 3.

机译：对3型登革热病毒具有特异性的单克隆抗体

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Mouse lymphocyte hybridomas were prepared by polyethylene glycol-mediated fusion of cells from a mouse plasmacytoma line with lymphocytes from a mouse hyperimmunized with dengue virus type 3 (dengue-3). Media from 50 hybrid colonies were screened; 46 of them showed antibody activity against dengue-3-infected cells as determined by an indirect immunofluorescent antibody technique. Dengue monoclonal antibody obtained after cloning one of these colonies demonstrated activity in hemagglutination inhibition and indirect immunofluorescent antibody assays with dengue-3 antigen, but not type 1, 2, and 4 antigens. In addition, this antibody activity could be removed from culture media only by absorption with dengue-3 antigen.

机译：小鼠淋巴细胞杂交瘤是通过聚乙二醇介导的小鼠浆细胞瘤细胞系细胞与用3型登革热病毒（dengue-3）超免疫的小鼠的淋巴细胞融合而制备的。筛选了来自50个杂交菌落的培养基。通过间接免疫荧光抗体技术确定，其中46例显示出针对登革3感染细胞的抗体活性。克隆这些菌落之一后获得的登革热单克隆抗体在血凝抑制和间接免疫荧光抗体测定中显示出活性，使用登革3抗原，但没有1、2和4型抗原。另外，仅通过用登革3抗原吸收，才能从培养基中除去该抗体活性。

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《Journal of Clinical Microbiology》 |1980年第1期|共5页
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D Dittmar; H G Haines; A Castro;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Development of an Antigen Capture Immunoassay Based on Monoclonal Antibodies Specific for Dengue Virus Serotype 2 Nonstructural Protein 1 for Early and Rapid Identification of Dengue Virus Serotype 2 Infections [J] . Li-wen Qiu, Biao Di, Kun Wen, Clinical and vaccine immunology: CVI . 2009,第1期

机译：基于特异性针对登革热病毒血清型2非结构蛋白1的单克隆抗体的抗原捕获免疫测定技术的开发，用于早期和快速鉴定登革热病毒血清型2感染。
2. Characterization and epitope mapping of Dengue virus type 1 specific monoclonal antibodies [J] . Wen-Hung Chen, Feng-Pai Chou, Yu-Kuo Wang, Virology Journal . 2017,第1期

机译：登革热病毒1型特异性单克隆抗体的表征和抗原决定簇定位
3. Formation of Infectious Dengue Virus Antibody Immune Complex In Vivo in Marmosets (Callithrix jacchus) After Passive Transfer of Anti-Dengue Virus Monoclonal Antibodies and Infection with Dengue Virus [J] . Moi Meng Ling, Ami Yasushi, Shirai Kenji, The American Journal of Tropical Medicine and Hygiene . 2015,第2期

机译：被动转移抗登革热病毒单克隆抗体并感染登革热病毒后，Mar猴（Callithrix jacchus）体内感染性登革热病毒抗体免疫复合物的形成。
4. IMPLEMENTATION OF A STRATEGY TO PRODUCE A BROADLY NEUTRALIZING MONOCLONAL ANTIBODY AGAINST ZIKA AND DENGUE VIRUSES [C] . Esmeralda Cuevas-Juarez, Laura A. Palomares Conference on vaccine technology VI . 2018

机译：实施针对寨卡病毒和登革热病毒的广泛中和性单克隆抗体的策略的实施
5. Molecular determinants of dengue virus type-2 critical for early events in antibody-dependent enhancement of infection. [D] . Chotiwan, Nunya. 2013

机译：2型登革热病毒分子决定因素对于抗体依赖性增强感染的早期事件至关重要。
6. Monoclonal antibodies specific for dengue virus type 3. [O] . D Dittmar, H G Haines, A Castro 1980

机译：对3型登革热病毒具有特异性的单克隆抗体
7. Development of an Antigen Capture Immunoassay Based on Monoclonal Antibodies Specific for Dengue Virus Serotype 2 Nonstructural Protein 1 for Early and Rapid Identification of Dengue Virus Serotype 2 Infections▿ [O] . Qiu, Li-wen, Di, Biao, Wen, Kun, 2008

机译：基于特异性针对登革热病毒血清型2非结构蛋白1的单克隆抗体的抗原捕获免疫分析方法的开发，用于早期和快速鉴定登革热病毒血清型2感染。
8. Dengue Virus Specific and Flavivirus Group Determinants Identified with Monoclonal Antibodies by Indirect Immunofluorescence [R] . Henchal, E. A., Gentry, M. K., McCown, J. M., 1982

机译：通过间接免疫荧光鉴定登革病毒特异性和黄病毒组确定的单克隆抗体

Monoclonal antibodies specific for dengue virus type 3.

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