Identification of a 25-kilodalton protein of Mycobacterium bovis BCG to distinguish BCG strains from Mycobacterium tuberculosis.

D Kumar; B S Srivastava; N B Singh; R Srivastava

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Identification of a 25-kilodalton protein of Mycobacterium bovis BCG to distinguish BCG strains from Mycobacterium tuberculosis.

机译：牛分枝杆菌BCG的25千达尔顿蛋白的鉴定可将BCG菌株与结核分枝杆菌区分开。

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Mycobacterium bovis BCG vaccine strains were compared with Mycobacterium tuberculosis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A 25-kDa protein observed in the BCG strains was absent in M. tuberculosis. Rabbit antibodies specific to the 25-kDa protein uniquely identified this protein in BCG strains but not in M. tuberculosis. It is suggested that the 25-kDa protein and polyclonal antibodies directed against this antigen can be exploited to distinguish BCG strains from M. tuberculosis.

机译：通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳将牛分枝杆菌BCG疫苗株与结核分枝杆菌进行了比较。在结核分枝杆菌中不存在在BCG菌株中观察到的25 kDa蛋白。对25 kDa蛋白具有特异性的兔抗体在BCG菌株中唯一鉴定了该蛋白，但在结核分枝杆菌中却没有。建议可以利用针对该抗原的25 kDa蛋白和多克隆抗体来区分BCG菌株和结核分枝杆菌。

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《Journal of Clinical Microbiology》 |1996年第1期|共3页
作者
D Kumar; B S Srivastava; N B Singh; R Srivastava;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. A Comprehensive Survey of Single Nucleotide Polymorphisms (SNPs) across Mycobacterium bovis Strains and M. bovis BCG Vaccine Strains Refines the Genealogy and Defines a Minimal Set of SNPs That Separate Virulent M. bovis Strains and M. bovis BCG Strains [J] . M. Carmen Garcia Pelayo, Swapna Uplekar, Andrew Keniry, Infection and immunity . 2009,第5期

机译：牛分枝杆菌菌株和牛分枝杆菌BCG疫苗株之间单核苷酸多态性（SNP）的全面调查完善了族谱，并定义了分离毒力牛分枝杆菌和牛分枝杆菌BCG株的最小SNP集。
2. Evolution of cell types and T-cell subsets in the spleens of Mycobacterium bovis BCG-resistant and M. bovis BCG-susceptible strains of mice after infection with M. bovis BCG. [J] . M Denis, A Forget, A C Miailhe, Infection and immunity . 1985,第1期

机译：牛分枝杆菌BCG感染后，牛分枝杆菌BCG抗性和牛分枝杆菌BCG易感株的小鼠脾脏中细胞类型和T细胞亚群的演变。
3. Mycobacterium bovis BCG vaccine fails to protect protein-deficient guinea pigs against respiratory challenge with virulent Mycobacterium tuberculosis. [J] . D N McMurray, M A Carlomagno, C L Mintzer, Infection and immunity . 1985,第2期

机译：牛分枝杆菌卡介苗不能保护蛋白质不足的豚鼠免受强力结核分枝杆菌的呼吸道攻击。
4. Isolated Strains of Nontuberculous Mycobacterium Interfere with Immune Responses Associated with Mycobacterium bovis BCG Vaccination [C] . Chunfang Wang, Huarui Qi, Xiuyun Jiang International Conference on Biotechnology, Chemical and Materials Engineering . 2014

机译：孤立的非萎缩分枝杆菌的菌株干扰与肉杆菌BCG疫苗接种的免疫应答
5. The identification and elimination of immunosuppressive Mycobacterium bovis BCG genes to create novel rBCG vectors that generate increased CD8+ T cell responses [D] . Panas, Michael William 2011

机译：鉴定和消除免疫抑制牛分枝杆菌BCG基因以创建产生增加的CD8 + T细胞反应的新型rBCG载体
6. Identification of a 25-kilodalton protein of Mycobacterium bovis BCG to distinguish BCG strains from Mycobacterium tuberculosis. [O] . D Kumar, B S Srivastava, N B Singh, 1996

机译：牛分枝杆菌BCG的25千达尔顿蛋白的鉴定可区分BCG菌株与结核分枝杆菌。
7. Identification of a 25-kilodalton protein of Mycobacterium bovis BCG to distinguish BCG strains from Mycobacterium tuberculosis [O] . D Kumar, B S Srivastava, N B Singh, 1996

机译：鉴定25千杆菌的肉毒杆菌BCG蛋白，以区分BCG菌株与结核分枝杆菌
8. Antileishmanial Activities of Macrophages from C3H/HeN and C3H/HeJ Mice Treated with Mycobacterium bovis Strain BCG. [R] . Pappas, M. G., Nacy, C. A. 1983

机译：用牛分枝杆菌菌株BCG处理C3H / HeN和C3H / HeJ小鼠巨噬细胞的肛门活动。

Identification of a 25-kilodalton protein of Mycobacterium bovis BCG to distinguish BCG strains from Mycobacterium tuberculosis.

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