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首页> 外文期刊>Journal of Clinical Microbiology >Heterogeneity and clonality among isolates of Mycobacterium kansasii: implications for epidemiological and pathogenicity studies.
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Heterogeneity and clonality among isolates of Mycobacterium kansasii: implications for epidemiological and pathogenicity studies.

机译：堪萨斯分枝杆菌分离株之间的异质性和克隆性：对流行病学和致病性研究的意义。

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The reservoir and transmission route of Mycobacterium kansasii are largely unknown. In addition, culturing of M. kansasii from human sources is not proof of disease because it may represent colonization rather than infection. Unfortunately, investigation of the epidemiology and pathogenicity of M. kansasii is complicated by evidence of heterogeneity within the species. A comprehensive study by detailed genotypic analysis of a large collection of M. kansasii isolates (n = 276) from various geographical sources within Europe was conducted. Five defined subtypes of M. kansasii were identified; of these subtypes, type I represents the most common isolate from humans. Although phylogenetic analysis confirmed its relationship to the other M. kansasii types, significant sequence divergence was found at the 16S-23S intergenic spacer. Analysis of the chromosomal polymorphism of type I demonstrated a marked clonal structure for this particular organism. Because M. kansasii is becoming a significant pathogen among immunodeficient hosts, future epidemiological and pathogenicity studies should take into consideration both the heterogeneity within the species and the apparent clonality of the most prevalent M. kansasii isolates infecting humans.
机译：堪萨斯分枝杆菌的贮藏和传播途径尚不清楚。此外，从人源培养堪萨斯分枝杆菌并不能证明疾病，因为它可能代表着殖民而不是感染。不幸的是，对堪萨斯分枝杆菌的流行病学和致病性的研究由于物种内异质性的证据而变得复杂。通过详细的基因型分析，对欧洲范围内来自各种地理来源的大量堪萨斯分枝杆菌菌株（n = 276）进行了全面研究。确定了堪萨斯分枝杆菌的五种确定的亚型。在这些亚型中，I型代表最常见的人类分离株。尽管系统发育分析证实了其与其他堪萨斯分枝杆菌的关系，但在16S-23S基因间隔区发现了明显的序列差异。对I型染色体多态性的分析表明，该特定生物具有明显的克隆结构。由于堪萨斯分枝杆菌正在成为免疫缺陷宿主中的重要病原体，因此未来的流行病学和致病性研究应同时考虑物种内的异质性和感染人类的​​最普遍的堪萨斯分枝杆菌菌株的表观克隆性。

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