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首页> 外文期刊>Journal of Clinical Microbiology >Antimicrobial susceptibility testing of Francisella tularensis with a modified Mueller-Hinton broth.
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Antimicrobial susceptibility testing of Francisella tularensis with a modified Mueller-Hinton broth.

机译：改良的Mueller-Hinton肉汤对弗朗西斯菌的药敏试验。

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A modified Mueller-Hinton broth was developed to perform antimicrobial susceptibility tests on Francisella tularensis. Adequate growth of the organism was obtained within 24 h of inoculation, and MICs could be read at that time. We tested 15 selected strains of F. tularensis and five reference quality control strains in this medium with 36 antimicrobial agents. The MICs of the aminoglycosides and tetracycline increased 1 to 3 dilutions in this medium compared with those in the usual medium, but the other antimicrobial agents were not consistently affected by the medium. Even though the medium caused an increase in MICs, the aminoglycosides and tetracyclines remained very active in vitro against F. tularensis. Other antimicrobial agents effective in vitro were chloramphenicol, erythromycin, ceftazidime, moxalactam, cefotaxime, ceftriaxone, and Sch 29482 (a cephalosporin).
机译：开发了一种改良的Mueller-Hinton肉汤，可对图拉尼弗朗西斯菌进行药敏试验。接种后24小时内即可获得足够的微生物生长，此时可读取MIC。我们在含有36种抗微生物剂的培养基中测试了15种选择的土拉弗朗西斯菌菌株和5种参考质量控制菌株。与普通培养基相比，该培养基中氨基糖苷类和四环素类化合物的MIC增加了1-3倍，但其他抗微生物剂不受该培养基的影响。即使培养基引起了MIC的增加，但氨基糖苷类和四环素类药物在体外仍对图拉弗雷索氏菌非常活跃。在体外有效的其他抗菌剂是氯霉素，红霉素，头孢他啶，莫拉西坦，头孢噻肟，头孢曲松和Sch 29482（头孢菌素）。

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