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首页> 外文期刊>Journal of Clinical Microbiology >Differentiation of human immunodeficiency virus type 1 (HIV-1) infections with HIV-2-cross-reacting antibody from mixed infections with HIV-1 and HIV-2 by serological absorption test.
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Differentiation of human immunodeficiency virus type 1 (HIV-1) infections with HIV-2-cross-reacting antibody from mixed infections with HIV-1 and HIV-2 by serological absorption test.

机译:通过血清吸收试验,将HIV-2交叉反应抗体与人类HIV-1和HIV-2混合感染的人类免疫缺陷病毒1型(HIV-1)感染区分开。

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摘要

The interpretation of dual seroreactivity with human immunodeficiency virus type 1 (HIV-1) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide. Some samples of sera from HIV-1-infected patients showed a serological cross-reaction with HIV-2, causing confusion regarding the serodiagnosis. Therefore, we tried to differentiate these serum samples from those containing real mixed infections with both types of virus. Sera from patients with HIV-1 infections with HIV-2 cross-reacting antibody in Japan were distinguished from sera from patients with mixed infections with HIV-1 and HIV-2 in West Africa by our serological cross-absorption test, which proved to be highly specific and useful for serodiagnosis.
机译:血液样本中与人类免疫缺陷病毒1型(HIV-1)和HIV-2双重血清反应的解释是全世界艾滋病研究人员面临的一个严重问题。 HIV-1感染患者的一些血清样品显示出与HIV-2的血清学交叉反应,导致血清学诊断混乱。因此,我们试图将这些血清样品与包含两种病毒真正混合感染的血清样品区分开。在我们的血清学交叉吸收测试中,日本的HIV-1感染了HIV-2交叉反应抗体的患者血清与西非的HIV-1和HIV-2混合感染患者的血清相区别。高度特异性,对血清学诊断很有用。

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