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首页> 外文期刊>Journal of Clinical Microbiology >Identification of Enterocytozoon bieneusi spores in respiratory samples from an AIDS patient with a 2-year history of intestinal microsporidiosis.
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Identification of Enterocytozoon bieneusi spores in respiratory samples from an AIDS patient with a 2-year history of intestinal microsporidiosis.

机译：从患有肠道小孢子虫病2年历史的AIDS患者的呼吸道样本中鉴定Enterocytozoon bieneusi孢子。

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Enterocytozoon bieneusi, a microsporidian parasite, has been recognized since 1985 as an agent of intestinal microsporidiosis leading to malabsorption syndrome, diarrhea, and weight loss in AIDS patients. Recently, however, we have identified E. bieneusi spores in the sputum, bronchoalveolar lavage, and stool samples of an AIDS patient with a 2-year history of intestinal microsporidiosis. The spores were characterized by Weber's chromotrope-based staining, immunofluorescence tests, and PCR. No microsporidia were detected in urine samples by the same techniques. PCR was performed with DNAs purified from specimens with E. bieneusi-, Encephalitozoon cuniculi-, Encephalitozoon hellem-, and Encephalitozoon (Septata) intestinalis-specific primers. Treatment with albendazole and loperamide resulted in an improvement of intestinal symptoms, without eradication of the parasite. To our knowledge, this is the second report of the identification of E. bieneusi spores in respiratory and enteric samples obtained from an AIDS patient. Although no pulmonary pathology could be established in either of these cases, it is now clear that E. bieneusi is capable of colonizing the respiratory tract and it is suggested that investigators should be aware of the possibility of finding E. bieneusi spores in respiratory secretions.
机译：自1985年以来，Enterocytozoon bieneusi（一种微孢子虫寄生虫）已被公认为是肠道微孢子虫病的一种药物，可导致AIDS患者吸收不良综合征，腹泻和体重减轻。但是，最近，我们在一名患有肠道小孢子虫病2年病史的AIDS患者的痰液，支气管肺泡灌洗液和粪便中鉴定出了比氏肠埃希菌孢子。孢子通过韦伯基于色谱的染色，免疫荧光测试和PCR进行表征。用相同的技术在尿液样本中未检测到小孢子虫。用从比氏肠杆菌，钩端螺旋体，地脑钩端螺旋体和庚子脑膜（Septata）肠特异性引物中纯化的DNA进行PCR。用阿苯达唑和洛哌丁胺治疗可改善肠道症状，而不会根除寄生虫。据我们所知，这是从艾滋病患者获得的呼吸道和肠溶性样品中鉴定比氏肠杆菌的第二份报告。尽管在这两种情况下都无法确定肺部病理，但现在很清楚，比埃希氏大肠杆菌能够在呼吸道中定殖，因此建议研究者应意识到在呼吸道分泌物中发现比氏埃希氏菌孢子的可能性。

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