Differentiation of primary from nonprimary genital herpes infections by a herpes simplex virus-specific immunoglobulin G avidity assay.

M Hashido; S Inouye; T Kawana

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Differentiation of primary from nonprimary genital herpes infections by a herpes simplex virus-specific immunoglobulin G avidity assay.

机译：通过单纯疱疹病毒特异性免疫球蛋白G亲和力分析区分原发性和非原发性生殖器疱疹感染。

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An immunoglobulin G (IgG) antibody avidity assay which uses protein-denaturing agents and a modification of an enzyme-linked immunosorbent assay have been investigated for their usefulness in distinguishing primary genital herpes simplex virus (HSV) infections from nonprimary infections. Forty-nine serum specimens from patients with primary, recurrent, and nonprimary first-episode genital herpes were studied. The clearest separation was obtained with 6 M urea treatment, giving mean avidity indices of 0.398 for sera < or = 100 days after the infection and 0.879 for sera > 100 days after the infection (P < 0.001). No significant difference in avidity indices was observed between the recurrent and nonprimary first-episode infections. Determination of the avidity of HSV-specific IgG will improve the diagnostic potential of HSV serology.

机译：已经研究了使用蛋白质变性剂和酶联免疫吸附测定法的修饰的免疫球蛋白G（IgG）抗体亲和力测定法在区分原发性生殖器单纯疱疹病毒（HSV）感染和非原发性感染方面的有用性。研究了来自原发性，复发性和非原发性第一性生殖器疱疹患者的49份血清标本。用6 M尿素处理可获得最清晰的分离，对于感染后100天或以下的血清，平均亲和力指数为0.398，对于感染后100天以上的血清，平均亲和力指数为0.879（P <0.001）。在复发性和非原发性首发感染之间没有发现亲和力指数的显着差异。确定HSV特异性IgG的亲和力将提高HSV血清学的诊断潜力。

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《Journal of Clinical Microbiology》 |1997年第7期|共3页
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M Hashido; S Inouye; T Kawana;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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专利

1. Herpes simplex virus-specific serum immunoglobulin a: detection in patients with primary or recurrent herpes infections and in healthy adults. [J] . M G Friedman, N Kimmel Infection and immunity . 1982,第1期

机译：单纯疱疹病毒特异性血清免疫球蛋白a：在患有原发性或复发性疱疹感染的患者以及健康成年人中进行检测。
2. Herpes simplex virus-specific serum immunoglobulin a: detection in patients with primary or recurrent herpes infections and in healthy adults. [J] . M G Friedman, N Kimmel Infection and immunity . 1982,第1期

机译：单纯疱疹病毒特异性血清免疫球蛋白a：在患有原发性或复发性疱疹感染的患者以及健康成年人中进行检测。
3. ANALYSIS OF HERPES SIMPLEX VIRUS-SPECIFIC T CELLS IN THE MURINE FEMALE GENITAL TRACT FOLLOWING GENITAL INFECTION WITH HERPES SIMPLEX VIRUS TYPE 2 [J] . Milligan GN, Bernstein DI Virology . 1995,第2期

机译：感染2型单纯疱疹病毒的雌性雌性生殖道中单纯疱疹病毒特异性T细胞的分析。
4. Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and "area pudenda" with low-power He-Ne laser or Acyclovir administered orally [C] . Mariano Velez-Gonzalez, Hospital del Mar, Barcelona, Effects of Low-Power Light on Biological Systems . 1996

机译：口服低功率He-Ne激光或阿昔洛韦治疗阴唇和面部单纯疱疹复发，生殖器和单纯性疱疹复发
5. A critical role and a critical period for herpes simplex virus-specific CD8+ T lymphocyte infiltration into the central nervous system: Impact on the development of stress-induced herpes simplex encephalitis. [D] . Anglen, Crystal S. 2003

机译：单纯疱疹病毒特异性CD8 + T淋巴细胞浸入中枢神经系统的关键作用和关键时期：对应激诱导的单纯疱疹性脑炎发展的影响。
6. Differentiation of primary from nonprimary genital herpes infections by a herpes simplex virus-specific immunoglobulin G avidity assay. [O] . M Hashido, S Inouye, T Kawana 1997

机译：通过单纯疱疹病毒特异性免疫球蛋白G亲和力分析区分原发性和非原发性生殖器疱疹感染。
7. Herpes Simplex Virus-Specific IgM, IgA and IgG Subclass Antibody Responses in Primary and Nonprimary Genital Herpes Patients [O] . Madoka Hashido, Takashi Kawana 1997

机译：单纯疱疹病毒特异性IgM，IgA和IgG亚类抗体抗体反应在原发性和非共生疱疹病患者中

Differentiation of primary from nonprimary genital herpes infections by a herpes simplex virus-specific immunoglobulin G avidity assay.

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