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首页> 外文期刊>Journal of Clinical Microbiology >Serum antibody response to Listeria monocytogenes, listerial excretion, and clinical characteristics in experimentally infected goats.
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Serum antibody response to Listeria monocytogenes, listerial excretion, and clinical characteristics in experimentally infected goats.

机译：血清抗体对单核细胞增生李斯特菌，利斯特氏菌排泄和实验感染山羊的临床特征的反应。

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摘要

We induced an experimental listeriosis in five goats by oral inoculation of Listeria monocytogenes serovar 1/2a. The resulting generalized bacteremia was reflected by systemic illness in four of the five animals inoculated and by excretion of L. monocytogenes in milk by all five animals. By using an enzyme immunoassay, we recorded a markedly enhanced immunoglobulin G (IgG) antibody response in the two youngest and most seriously ill test animals. In these, the elimination of L. monocytogenes from the gastrointestinal tract occurred simultaneously with the development of the highest antibody levels at 14 to 15 days postinoculation. In the case of the oldest test animal, a preexisting, persistent IgG antibody response was recorded which was associated with the total absence of clinical symptoms and the shortest observed fecal carriage of L. monocytogenes, lasting for only 3 days. Two animals remained practically seronegative, and an IgM antibody response was not recorded for any of the animals. The findings suggest that an association exists between the humoral immune defense against Listeria infections, the clinical course of the infection, and the elimination of the Listeria organisms from the gastrointestinal tract.
机译：我们通过口服接种单核细胞增生性李斯特菌血清素1 / 2a诱导了五只山羊的实验性李斯特菌病。所产生的普遍菌血症通过接种的五只动物中的四只系统性疾病和所有五只动物在牛奶中单核细胞增生李斯特菌的排泄反映出来。通过使用酶免疫测定，我们在两只最年轻，病情最严重的试验动物中记录了明显增强的免疫球蛋白G（IgG）抗体反应。在这些中，在接种后14至15天与最高抗体水平的发展同时发生从胃肠道消除单核细胞增生李斯特菌。在最老的测试动物的情况下，记录了先前存在的，持续存在的IgG抗体应答，这与完全没有临床症状和观察到的最短的单核细胞增生李斯特菌粪便运输有关，仅持续3天。两只动物实际上保持血清阴性，并且没有记录任何动物的IgM抗体应答。这些发现表明，针对李斯特菌感染的体液免疫防御，感染的临床过程以及从胃肠道消除李斯特菌的生物之间存在关联。

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