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首页> 外文期刊>Journal of Clinical Microbiology >Clonal Distribution of Disease-Associated and Healthy Carrier Isolates of Neisseria meningitidis between 1983 and 2005 in Cuba
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Clonal Distribution of Disease-Associated and Healthy Carrier Isolates of Neisseria meningitidis between 1983 and 2005 in Cuba

机译：1983年至2005年间古巴脑膜炎奈瑟氏球菌疾病相关健康隔离株的克隆分布

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In response to epidemic levels of serogroup B meningococcal disease in Cuba during the 1980s, the VA-MENGOC-BC vaccine was developed and introduced into the National Infant Immunization Program in 1991. Since then the incidence of meningococcal disease in Cuba has returned to the low levels recorded before the epidemic. A total of 420 Neisseria meningitidis strains collected between 1983 and 2005 in Cuba were analyzed by multilocus sequence typing (MLST). The set of strains comprised 167 isolated from disease cases and 253 obtained from healthy carriers. By MLST analysis, 63 sequence types (STs) were identified, and 32 of these were reported to be a new ST. The Cuban isolates were associated with 12 clonal complexes; and the most common were ST-32 (246 isolates), ST-53 (86 isolates), and ST-41/44 (36 isolates). This study also showed that the application of VA-MENGOC-BC, the Cuban serogroup B and C vaccine, reduced the frequency and diversity of hypervirulent clonal complexes ST-32 (vaccine serogroup B type-strain) and ST-41/44 and also affected other lineages. Lineages ST-8 and ST-11 were no longer found during the postvaccination period. The vaccine also affected the genetic composition of the carrier-associated meningococcal isolates. The number of carrier isolates belonging to hypervirulent lineages decreased significantly after vaccination, and ST-53, a sequence type common in carriers, became the predominant ST.
机译：为了响应1980年代古巴B型脑膜炎球菌血清型的流行，研制了VA-MENGOC-BC疫苗，并于1991年将其引入国家婴儿免疫计划。此后，古巴的脑膜炎球菌病的发病率恢复到较低水平流行之前记录的水平。通过多基因座序列分型（MLST）分析了1983年至2005年在古巴收集的总共420株脑膜炎奈瑟氏球菌。这套菌株包括从疾病病例中分离的167株和从健康携带者获得的253株。通过MLST分析，鉴定出63种序列类型（ST），其中32种报告为新的ST。古巴分离物与12个克隆复合体有关;最常见的是ST-32（246个菌株），ST-53（86个菌株）和ST-41 / 44（36个菌株）。这项研究还表明，古巴B和C血清群疫苗VA-MENGOC-BC的使用降低了高毒力克隆复合体ST-32（B型疫苗血清群）和ST-41 / 44的频率和多样性，并且影响了其他血统。疫苗接种后不再发现ST-8和ST-11世系。疫苗还影响了与载体相关的脑膜炎球菌分离株的遗传组成。接种疫苗后，属于高毒力谱系的载体分离株的数量显着减少，ST-53（在载体中常见的序列类型）成为主要的ST。

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