Low Concentrations of Mupirocin in the Pharynx following Intranasal Application May Contribute to Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus

Hiroshi Watanabe; Hironori Masaki; Norichika Asoh; Kiwao Watanabe; Kazunori Oishi; Shinobu Kobayashi; Akiyoshi Sato; Rinya Sugita; Tsuyoshi Nagatake

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Low Concentrations of Mupirocin in the Pharynx following Intranasal Application May Contribute to Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus

机译：鼻内应用后咽中低浓度的莫匹罗星可能导致耐甲氧西林金黄色葡萄球菌的莫匹罗星耐药

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We describe a patient with methicillin-resistantStaphylococcus aureus (MRSA) colonizing the pharynx. The MIC of mupirocin was 0.25 μg/ml before treatment and increased after treatment to 8 μg/ml. Using pulsed-field gel electrophoresis, we confirmed that the genotypes of MRSA that colonized the pharynx before and after the use of mupirocin were identical. We measured the delivery of mupirocin to the pharynx in three normal volunteers and two patients. Low concentrations of mupirocin were present in the pharynx in all cases 10 min to 3 days after intranasal application. Our data suggested that low concentrations of the drug in the pharynx after intranasal application of mupirocin ointment might explain the selection of mupirocin resistance in MRSA.

机译：我们描述了耐甲氧西林的金黄色葡萄球菌（MRSA）定植在咽部的患者。治疗前莫匹罗星的MIC为0.25μg/ ml，治疗后增加至8μg/ ml。使用脉冲场凝胶电泳，我们确认了在使用莫匹罗星之前和之后在咽部定殖的MRSA的基因型是相同的。我们在三名正常志愿者和两名患者中测量了莫匹罗星向咽的递送。鼻内应用后10分钟至3天，所有病例的咽中都存在低浓度的莫匹罗星。我们的数据表明，鼻内应用莫匹罗星软膏后咽部药物浓度低可能解释了MRSA对莫匹罗星耐药的选择。 展开▼

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《Journal of Clinical Microbiology》 |2001年第10期|共3页

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Hiroshi Watanabe; Hironori Masaki; Norichika Asoh; Kiwao Watanabe; Kazunori Oishi; Shinobu Kobayashi; Akiyoshi Sato; Rinya Sugita; Tsuyoshi Nagatake;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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专利

1. Acquisition of High-Level Mupirocin Resistance and Its Fitness Cost among Methicillin-Resistant Staphylococcus aureus Strains with Low-Level Mupirocin Resistance [J] . Kanokporn Mongkolrattanothai, Lisa Pumfrey, Peggy Mankin, Journal of Clinical Microbiology . 2009,第12期

机译：耐甲氧西林金黄色葡萄球菌菌株对莫匹罗星耐药的高水平对莫匹罗星的耐药性及其适应性成本

2. Clinical and cost ineffectiveness of preoperative screening for methicillin-resistant Staphylococcus aureus and intranasal mupirocin in preventing methicillin-resistant S aureus infections in cardiothoracic surgery. [J] . Cunha BA, Thekkel V, Schoch P, American Journal of Infection Control . 2011,第3期

机译：术前筛查耐甲氧西林金黄色葡萄球菌和鼻内莫匹罗星预防心胸外科手术中耐甲氧西林金黄色葡萄球菌感染的临床和费用无效。

3. Prevalence of qacA/B Genes and Mupirocin Resistance Among Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates in the Setting of Chlorhexidine Bathing Without Mupirocin [J] . Warren David K., Prager Martin, Munigala Satish, Infection control and hospital epidemiology . 2016,第5期

机译：甲氧西林抗金黄色葡萄球菌（MRSA）在没有Mupirocin的氯己定浴中的含量（MRSA）中的甲氧西林抗性金黄色葡萄球菌（MRSA）的血管素抗性

4. Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa. [C] . David Medina, Thomas J. Webster Society for Biomaterials annual meeting and exposition . 2018

机译：金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌（MRSA），大肠杆菌和铜绿假单胞菌制成的具有抗菌特性的生物硒纳米粒子的合成与表征。

5. Characterization and Isolation of Fecal Indicator Bacteria, Staphylococcus aureus, and Methicillin-resistant Staphylococcus aureus from Pacific Northwest Marine Beach Samples. [D] . Gilmore, Shonnessy. 2012

机译：粪便指示菌，金黄色葡萄球菌和耐甲氧西林的金黄色葡萄球菌的特征和分离来自西北太平洋海洋海滩样品。

6. Note: Low Concentrations of Mupirocin in the Pharynx following Intranasal Application May Contribute to Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus [O] . Hiroshi Watanabe, Hironori Masaki, Norichika Asoh, 2001

机译：注意：鼻内应用后咽中的莫匹罗星浓度低可能会导致耐甲氧西林金黄色葡萄球菌对莫匹罗星的耐药性

7. Low Concentrations of Mupirocin in the Pharynx following Intranasal Application May Contribute to Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus [O] . Watanabe, Hiroshi, Masaki, Hironori, Asoh, Norichika, 2001

机译：鼻内应用后咽中的莫匹罗星浓度低，可能会导致耐甲氧西林金黄色葡萄球菌的莫匹罗星耐药

1. 耐甲氧西林金黄色葡萄球菌对莫匹罗星、夫西地酸和瑞他莫林的耐药性分析 [J] . 陈雯静 ,何春燕 ,杨涵 . 检验医学 . 2019,第001期

2. 探讨莫匹罗星与贝复济联合治疗烧伤患者残余创面并耐甲氧西林金黄色葡萄球菌(MRSA)感染的效果 [J] . 刘国战 ,宋艳冰 . 医学美学美容 . 2020,第005期

3. 重症监护病房新生儿耐甲氧西林金黄色葡萄球菌定植情况及莫匹罗星去定植效果 [J] . 黄雨茅 ,金伟敏 ,项文娜 . 中华围产医学杂志 . 2017,第005期

4. 莫匹罗星对鼻腔内耐甲氧西林金黄色葡萄球菌的去定植效果分析 [J] . 刘金萍 ,董宏亮 . 中国药业 . 2015,第021期

5. 金黄色葡萄球菌对莫匹罗星和氯己定的耐药研究进展 [J] . 严明 ,吴建国 ,黄文祥 . 中国感染与化疗杂志 . 2016,第004期

6. 莫匹罗星的药理作用及细菌耐药性 [C] . . 2008全国中西医结合皮肤性病学术会议 . 2008

7. 金黄色葡萄球菌的分子特征分析及其对莫匹罗星的耐药机制研究 [A] . 宋燕 . 2013

1. Primers and probes for detecting methicillin-resistant Staphylococcus aureus, and method for detecting methicillin-resistant Staphylococcus aureus with them [P] . 外国专利： JP6007652B2 . 2016-10-12

机译：用于检测耐甲氧西林金黄色葡萄球菌的引物和探针，以及用于检测耐甲氧西林金黄色葡萄球菌的方法

2. PRIMER AND PROBE FOR DETECTING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS, AND METHOD FOR DETECTING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS USING THE SAME [P] . 外国专利： JP2013048619A . 2013-03-14

机译：用于检测耐甲氧西林金黄色葡萄球菌的引物和探针，以及使用相同方法检测耐甲氧西林金黄色葡萄球菌的方法

3. PRIMER AND PROBE FOR DETECTING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS, AND METHOD FOR DETECTING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS USING THE SAME [P] . 外国专利： JP2013048620A . 2013-03-14

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Low Concentrations of Mupirocin in the Pharynx following Intranasal Application May Contribute to Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus

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