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首页> 外文期刊>Journal of Clinical Microbiology >Beijing Genotype of Mycobacterium tuberculosis Is Significantly Associated with Human Immunodeficiency Virus Infection and Multidrug Resistance in Cases of Tuberculous Meningitis
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Beijing Genotype of Mycobacterium tuberculosis Is Significantly Associated with Human Immunodeficiency Virus Infection and Multidrug Resistance in Cases of Tuberculous Meningitis

机译：北京结核分枝杆菌的基因型与结核性脑膜炎病例中的人类免疫缺陷病毒感染和多药耐药性显着相关

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摘要

Multidrug-resistant tuberculous meningitis is fatal without rapid diagnosis and use of second-line therapy. It is more common in human immunodeficiency virus (HIV)-positive patients. Beijing genotype strains of Mycobacterium tuberculosis are associated with drug resistance, particularly multidrug resistance, and their prevalence is increasing worldwide. The prevalence of Beijing genotype strains among Mycobacterium tuberculosis isolates from the cerebrospinal fluid of HIV-positive (n = 35) and HIV-negative (n = 187) patients in Ho Chi Minh City was determined. The Beijing genotype was significantly associated with HIV status (odds ratio [OR] = 2.95 [95% confidence interval {CI}, 1.38 to 6.44]; P = 0.016), resistance to any drug (OR = 3.34 [95% CI, 1.87 to 5.95]; P < 0.001) and multidrug resistance (Fisher's exact test; P = 0.001). The association of the Beijing genotype with drug resistance was independent of HIV status. This is the first report of Beijing genotype association with HIV status, which may be an association unique to tuberculous meningitis.
机译：没有快速诊断和使用二线治疗，耐多药结核性脑膜炎是致命的。在人免疫缺陷病毒（HIV）阳性患者中更常见。北京结核分枝杆菌的基因型菌株与耐药性有关，尤其是对多药耐药性，在世界范围内其流行率正在上升。 HIV阳性（ n = 35）和HIV阴性（ n ）脑脊液中结核分枝杆菌分离株中北京基因型菌株的流行= 187）确定了胡志明市的患者。北京基因型与艾滋病毒状况显着相关（比值比[OR] = 2.95 [95％置信区间{CI}，1.38至6.44]; P = 0.016），对任何药物的耐药性（OR = 3.34 [95％CI，1.87至​​5.95]; P <0.001）和多药耐药性（Fisher精确检验; P = 0.001）。北京基因型与耐药性的相关性与艾滋病毒感染状况无关。这是北京基因型与艾滋病毒感染状况相关的首次报道，这可能是结核性脑膜炎所特有的。

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