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首页> 外文期刊>Journal of Clinical Microbiology >Laboratory-Based Surveillance and Molecular Epidemiology of Influenza Virus in Taiwan
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Laboratory-Based Surveillance and Molecular Epidemiology of Influenza Virus in Taiwan

机译：台湾基于实验室的流感病毒监测和分子流行病学

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A laboratory-based surveillance network of 11 clinical virological laboratories for influenza viruses was established in Taiwan under the coordination of the Center for Disease Control and Prevention (CDC), Taiwan. From October 2000 to March 2004, 3,244 influenza viruses were isolated, including 1,969 influenza A and 1,275 influenza B viruses. The influenza infections usually occurred frequently in winter in the northern hemisphere. However, the influenza seasonality in Taiwan was not clear during the four seasons under investigation. For example, the influenza A viruses peaked during the winters of 2001, 2002, and 2003. However, some isolated peaks were also found in the summer and fall (June to November) of 2001 and 2002. An unusual peak of influenza B also occurred in the summer of 2002 (June to August). Phylogenetic analysis shows that influenza A isolates from the same year were often grouped together. However, influenza B isolates from the year 2002 clustered into different groups, and the data indicate that both B/Victoria/2/87-like and B/Yamagata/16/88-like lineages of influenza B viruses were cocirculating. Sequence comparison of epidemic strains versus vaccine strains shows that many vaccine-like Taiwanese strains were circulating at least 2 years before the vaccine strains were introduced. No clear seasonality of influenza reports in Taiwan occurred in contrast to other more continental regions.
机译：在台湾疾病控制与预防中心（CDC）的协调下，在台湾建立了由11个流感病毒临床病毒实验室组成的基于实验室的监视网络。从2000年10月到2004年3月，共分离出3244种流感病毒，其中包括1969种甲型流感病毒和1275种乙型流感病毒。流感感染通常在北半球的冬季频繁发生。但是，在调查的四个季节中，台湾的流感季节性不明确。例如，甲型流感病毒在2001、2002和2003年的冬季达到峰值。但是，在2001和2002年的夏季和秋季（六月至十一月）也发现了一些孤立的高峰。在2002年夏天（6月至8月）。系统发育分析表明，同一年的甲型流感病毒分离株通常被分组在一起。但是，2002年的B型流感分离株聚集在不同的组中，数据表明B / Victoria / 2/87型和B / Yamagata / 16/88型B型流感病毒谱系正在共同传播。流行毒株与疫苗毒株的序列比较表明，许多疫苗样台湾毒株在引入疫苗毒株之前至少流通了2年。与其他大陆地区相比，台湾没有明显的季节性流感报告。

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