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Hospital-based surveillance and molecular epidemiology of rotavirus infection in Taiwan, 2005-2007

机译：2005-2007年台湾医院轮状病毒感染的监测和分子流行病学

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To determine the distribution of rotavirus strains and facilitate vaccine policy decisions in Taiwan, active hospital-based gastroenteritis surveillance was conducted in three sentinel hospitals. From 1 January 2005 to 31 December 2007, a total of 3435 children less than 5 years old with gastroenteritis were enrolled. The presence of rotavirus was documented by enzyme immunoassay (EIA), and the G and P genotypes were determined by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing methods. Results confirmed that 856 (25%) of these gastroenteritis admissions were EIA-positive for rotavirus and 448 (52%) of the rotavirus positive admissions were less than 2 years old. The most prevalent rotavirus genotypes were G1P[8] (40%), followed by strains G3P[8] (27%), and G9P[8] (17%). These data will help inform decisions as to whether rotavirus vaccine should be considered for inclusion into Taiwan's National Immunisation Programme.
机译：为了确定轮状病毒株的分布并促进台湾疫苗政策的决定，在三家前哨医院进行了积极的基于医院的胃肠炎监测。从2005年1月1日到2007年12月31日，共有3435名5岁以下的胃肠炎儿童入组。轮状病毒的存在通过酶免疫法（EIA）记录，G和P基因型通过逆转录聚合酶链反应（RT-PCR）和测序方法确定。结果证实，这些胃肠炎入院者中有856名（25％）轮状病毒EIA阳性，而448名（52％）轮状病毒阳性入院者不到2岁。轮状病毒最普遍的基因型是G1P [8]（40％），其次是菌株G3P [8]（27％）和G9P [8]（17％）。这些数据将有助于做出有关是否应考虑将轮状病毒疫苗纳入台湾国家免疫计划的决定。

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